ArticleScience translational medicine2020
Open access · greenAbstract read
In one paragraph
Article in Science translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
1.0field-weighted citation impact, top 22% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Cross-ancestry analysis of gestational diabetes mellitus identifies novel loci, drug targets and biological pathways.Frontiers in endocrinology · 2026Pooled it
- The Genetics of Atypical Femur Fractures-a Systematic Review.Current osteoporosis reports · 2021Pooled it
- New Immunological Insights into Bisphosphonate-Related Osteonecrosis of the Jaw: A Multidimensional Reappraisal from Molecular Switches to Clinical Phenotypes.Current issues in molecular biology · 2026Review
- Loss of ATRAID in Late-Onset, Non-Syndromic Retinitis Pigmentosa.Investigative ophthalmology & visual science · 2026Article
- Exogenous activation of the adhesion GPCR ADGRD1/GPR133 protects against bone loss by negatively regulating osteoclastogenesis.Science advances · 2025Article
- Focusing on spinal stenosis: emerging discoveries concerning Alendronate-induced risks and genetic drug targets.Journal of orthopaedic surgery and research · 2025Article
- Exome-wide association study reveals 7 functional variants associated with ex-vivo drug response in acute myeloid leukemia patients.BMC medical genomics · 2025Article
- SEAD reference panel with 22,134 haplotypes boosts rare variant imputation and genome-wide association analysis in Asian populations.Nature communications · 2024Article
- Gene-based association analysis of a large patient cohort provides insights into genetics of atypical femur fractures.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Cold exposure impacts DNA methylation patterns in cattle sperm.Frontiers in genetics · 2024Article
- Functional characterization of all-trans retinoic acid-induced differentiation factor (ATRAID).FEBS open bio · 2023Article
- Pathophysiological mechanism of acute bone loss after fracture.Journal of advanced research · 2023Review
- Whole Exome Sequencing in Two Southeast Asian Families With Atypical Femur Fractures.JBMR plus · 2022Article
- Alveolar macrophages: Achilles' heel of SARS-CoV-2 infection.Signal transduction and targeted therapy · 2022Review
- Review
- Osteoclast Fusion: Physiological Regulation of Multinucleation through Heterogeneity-Potential Implications for Drug Sensitivity.International journal of molecular sciences · 2020Review
- Epigenetic Regulators Involved in Osteoclast Differentiation.International journal of molecular sciences · 2020Review
- Gene linked to adverse effects of osteoporosis drug.Nature reviews. Endocrinology · 2020Article
Corrections and comments
- Commented on by
Authors and funding
38 authors at 14 institutions in 5 countries.
Lauren E SurfaceDepartment of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.ORCID 0000-0003-4055-0237
Damon T BurrowDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-8479-1449
Jinmei LiDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-1173-9738
Jiwoong ParkDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0001-7877-8259
Sandeep KumarDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-1049-7191
Cheng LyuDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-0345-8143
Niki SongDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-5952-4517
Zhou YuDepartment of Molecular and Cellular Biology, Department of Chemistry and Chemical Biology, Faculty of Arts and Sciences Center for Systems Biology, Harvard University, Cambridge, MA 02138, USA.
Abbhirami RajagopalDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.
Yangjin BaeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0003-2397-0192
Brendan H LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.ORCID 0000-0001-8573-4211
Steven MummDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0001-9267-4413
Charles C GuDivision of Biostatistics, Washington University School of Medicine, 660 S. Euclid Ave., Campus Box 8067, St. Louis, MO 63110, USA.ORCID 0000-0002-8527-8145
Jonathan C BakerMallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd., St. Louis, MO 63110, USA.ORCID 0000-0001-6078-612X
Mahshid MohseniDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Melissa SumDivision of Endocrinology, Diabetes and Metabolism, NYU Langone Health, 530 1st Ave., Schwartz 5E., New York, NY 10016, USA.
Margaret HuskeyDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.
Shenghui DuanDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-3992-2059
Vinieth N BijankiCenter for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St. Louis, MO 63110, USA.ORCID 0000-0003-4275-8920
Roberto CivitelliDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0003-4076-4315
Michael J GardnerDepartment of Orthopedic Surgery, Stanford University, 450 Broadway Street, Redwood City, CA 94063, USA.
Chris M McAndrewDepartment of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.ORCID 0000-0003-4854-2311
William M RicciHospital for Special Surgery Main Campus-Belaire Building, 525 East 71st Street 2nd Floor, New York, NY 10021, USA.
Christina A GurnettDepartment of Orthopedic Surgery, Washington University School of Medicine, 4938 Parkview Place, St. Louis, MO 63110, USA.ORCID 0000-0001-9129-315X
Kathryn DiemerDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0003-3712-3656
Fei WanDepartment of Surgery, Washington University School of Medicine, Campus Box 8109, 4590 Children's Place, Suite 9600, St. Louis, MO 63110, USA.ORCID 0000-0002-8311-5553
Christina L CostantinoMassachusetts General Hospital Cancer Center and Department of Surgery, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0002-4525-3533
Kristen M ShannonMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Noopur RajeMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.
Thomas B DodsonDepartment of Oral and Maxillofacial Surgery, Massachusetts General Hospital and Harvard School of Dental Medicine, Boston, MA 02114, USA.ORCID 0000-0002-4659-8322
Daniel A HaberMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA 02114, USA.ORCID 0000-0003-1378-6551
Jan E CaretteDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.
Malini VaradarajanOncology Disease Area, Novartis Institutes for BioMedical Research, Cambridge, CA 02140, USA.ORCID 0000-0002-5271-8116
Thijn R BrummelkampOncode Institute, Division of Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066CX Amsterdam, Netherlands.ORCID 0000-0002-3066-7071
Kivanc BirsoyThe Rockefeller University, 1230 York Ave., New York, NY 10065, USA.ORCID 0000-0002-7579-9895
David M SabatiniHoward Hughes Medical Institute (HHMI), Chevy Chase, MD 20815, USA.ORCID 0000-0002-1446-7256
Gabe HallerDepartment of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S. Euclid Ave., St. Louis, MO 63110, USA.ORCID 0000-0002-3884-5776
Timothy R PetersonDivision of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, BJC Institute of Health, 425 S. Euclid Ave., St. Louis, MO 63110, USA. timrpeterson@wustl.edu.ORCID 0000-0002-7749-7129
Washington University in St. Louis · USBaylor College of Medicine · USHarvard University · USCenter for Systems Biology · USHoward Hughes Medical Institute · USShriners Hospitals for Children - Erie · USStanford University · USAustrian Academy of Sciences · ATHospital for Special Surgery · USMallinckrodt (United States) · USMassachusetts General Hospital · USNovartis (Switzerland) · CHNYU Langone Health · USRockefeller University · US
Funding
Washington University Center for Cellular ImagingP30CA091842 · NCI · WASHINGTON UNIVERSITY · PI TIMOTHY J. EBERLEIN · 2001 to 2026
$128.0MPRE-DOCTORAL TRAINING IN THE BIOLOGICAL SCIENCEST32GM007287 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI BELL, STEPHEN P., KEATING, AMY E · 1985 to 2019
$40.8MProject 3: Collagen post-translational modification and cross-linking in OIP01HD070394 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN · 2011 to 2020
$13.4MHematology Training ProgramT32DK060445 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI GOODELL, MARGARET A. · 2002 to 2023
$8.3MModeling Metastasis and Acquired Drug Resistance Using Circulating Tumor CellsR01CA129933 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel A. Haber · 2008 to 2026
$7.5MRegulation of the mTOR Pathway By NutrientsR01CA103866 · NCI · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2004 to 2021
$7.0MResource Based Center for Musculoskeletal Biology and Medicine (Overall Application)P30AR074992 · NIAMS · WASHINGTON UNIVERSITY · PI MATTHEW J SILVA · 2019 to 2026
$6.8MThe Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7MTRANSLATIONAL CONTROL BY RAPAMYCIN-SENSITIVE SIGNALINGR01AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI WEISSMAN, JONATHAN S. · 2000 to 2021
$4.9MNovel Components of the mTORC1 and mTORC2 PathwaysR37AI047389 · NIAID · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI SABATINI, DAVID M. · 2010 to 2019
$4.8MGenetic Factors of Bone Loss in Older Adults Taking AntidepressantsR01AR073017 · NIAMS · WASHINGTON UNIVERSITY · PI PETERSON, TIMOTHY R · 2018 to 2021
$1.6MDeciphering Mechanisms of Nitrogen-Containing Bisphosphonates - Admin SupplementR00AR073903 · NIAMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SURFACE, LAUREN ELIZABETH · 2022 to 2024
$803kNCI NIH HHS P30 CA091842NCI NIH HHS R01 CA103866NCI NIH HHS R01 CA129933NIAID NIH HHS R01 AI047389NIAID NIH HHS R37 AI047389NIAMS NIH HHS K99 AR073903NIAMS NIH HHS P30 AR057235NIAMS NIH HHS P30 AR074992NIAMS NIH HHS R00 AR073903NIAMS NIH HHS R01 AR073017NIA NIH HHS K99 AG047255NIA NIH HHS R00 AG047255NICHD NIH HHS P01 HD070394NIDDK NIH HHS T32 DK060445NIGMS NIH HHS T32 GM007287
Abstract
Nitrogen-containing bisphosphonates (N-BPs), such as alendronate, are the most widely prescribed medications for diseases involving bone, with nearly 200 million prescriptions written annually. Recently, widespread use of N-BPs has been challenged due to the risk of rare but traumatic side effects such as atypical femoral fracture (AFF) and osteonecrosis of the jaw (ONJ). N-BPs bind to and inhibit farnesyl diphosphate synthase, resulting in defects in protein prenylation. Yet, it remains poorly understood what other cellular factors might allow N-BPs to exert their pharmacological effects. Here, we performed genome-wide studies in cells and patients to identify the poorly characterized gene,
Indexed as
DiphosphonatesNitrogenAlendronateAnimalsBone and BonesHumansMiceOsteoclastsAlendronateDiphosphonatesNitrogen
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.