Evidence map›Paper›PMID 32434782›Full record

ArticleJournal of clinical microbiology2020

Impact of Rapid Antimicrobial Susceptibility Testing in Gram-Negative Rod Bacteremia: a Quasi-experimental Study.

Catherine Anne Hogan, Bertrand Ebunji, Nancy Watz, Kristopher Kapphahn, Joseph Rigdon, Emily Mui, Lina Meng, William Alegria, Marisa Holubar, Stanley Deresinski and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
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  6. Rapid AST in practice - a workflow analysis of the QuickMICFrontiers in cellular and infection microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Catherine Anne HoganDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA.
Bertrand EbunjiClinical Microbiology Laboratory, Stanford Health Care, Palo Alto, California, USA.
Nancy WatzClinical Microbiology Laboratory, Stanford Health Care, Palo Alto, California, USA.
Kristopher KapphahnQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Joseph RigdonQuantitative Sciences Unit, Stanford University, Stanford, California, USA.
Emily MuiDepartment of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA.
Lina MengDepartment of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA.
William AlegriaDepartment of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA.
Marisa HolubarDepartment of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA.
Stanley DeresinskiDepartment of Quality, Patient Safety and Effectiveness, Stanford University School of Medicine, Stanford, California, USA.
Niaz BanaeiDepartment of Pathology, Stanford University School of Medicine, Stanford, California, USA nbanaei@stanford.edu.
National Patient Safety Foundation · USStanford University · USStanford Health Care · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Clinical justification for rapid antimicrobial susceptibility testing (AST) in Gram-negative rod (GNR) bacteremia is compelling; however, evidence supporting its value is sparse. We investigated the impact of rapid AST on clinical and antimicrobial stewardship outcomes in real-world practice. We performed a before-and-after quasi-experimental study from February 2018 to July 2019 at a tertiary hospital of the 24-h/day, 7-day/week implementation of the direct Vitek 2 AST method from positive blood culture broth for GNR bacteremia with electronic isolate-specific de-escalation comments and daytime antibiotic stewardship program (ASP) intervention. The primary outcome was time to appropriate antibiotic escalation or de-escalation, and secondary outcomes included time to oral antibiotic stepdown, hospital length of stay (LOS), all-cause 30-day mortality, 7-day incidence of acute kidney injury (AKI), and 30-day incidence of

Indexed as

Antimicrobial StewardshipBacteremiaGram-Negative Bacterial InfectionsAdultAnti-Bacterial AgentsGram-Negative BacteriaHumansLength of StayAnti-Bacterial Agentsantibiotic stewardshipbacteremiaGram-negative bacteriarapid diagnostic tests

Identifiers

PMID32434782
PMCPMC7448654
OpenAlexW3025632047

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.