Evidence map›Paper›PMID 32434220›Full record

ArticleThe Journal of cell biology2020

Mitochondrial translation, dynamics, and lysosomes combine to extend lifespan.

Levi Ali, Cole M Haynes

Abstract readComment
In one paragraph

Article in The Journal of cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. The conserved autoimmune-disease risk geneProceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Levi AliDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.
Cole M HaynesDepartment of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this issue, Liu et al. (2019. J. Cell. Biol.https://doi.org/10.1083/jcb.201907067) find that the inhibition of mitochondrial ribosomes in combination with impaired mitochondrial fission or fusion increases C. elegans lifespan by activating the transcription factor HLH-30, which promotes lysosomal biogenesis.

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsBasic Helix-Loop-Helix ProteinsLongevityLysosomesMitochondrial DynamicsBasic Helix-Loop-Helix ProteinsCaenorhabditis elegans ProteinsHLH-30 protein, C elegans

Identifiers

PMID32434220
PMCPMC7265329

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.