ArticlePhysics in medicine and biology2020
Roadmap toward the 10 ps time-of-flight PET challenge.
Article in Physics in medicine and biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.
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Who cites it
76 citing papers in PubMed, 250 citations in OpenAlex.
- Applications of artificial intelligence in nuclear medicine.Zeitschrift fur medizinische Physik · 2026Review
- Performance of detector modules designed for the NeuroSphere brain PET system.Medical physics · 2026Article
- Potential and challenges of Positron Emission Tomography beyond conventional preclinical and clinical imaging.Zeitschrift fur medizinische Physik · 2026Review
- Improving dual-panel in-beam PET imaging for proton therapy monitoring using 3D U-Net.Medical physics · 2026Article
- Realizing 303 ps Ultrafast Scintillation Time in 2-Inch CsPbClMaterials (Basel, Switzerland) · 2026Article
- Ultrafast scintillating metal-organic framework films.Nature communications · 2026Article
- Image reconstruction and elongation artifact reduction for a dual-panel dedicated prostate PET scanner.Medical physics · 2026Article
- Time-of-Flight Requirements to Mitigate Blurring Induced by Annihilation Photon Acollinearity.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Optimized Photoemission from Organic Molecules in 2D Layered Halide Perovskites.Journal of the American Chemical Society · 2026Article
- Strong ultrafast nonlinear optical response from megaelectronvolt electrons in semiconductors.Nature photonics · 2026Article
- Current Status of Cherenkov-Based Gamma Detectors for TOF-PET and Proton Range Verification.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Harnessing Self-Sensitized Scintillation by Supramolecular Engineering of CsPbBrAdvanced materials (Deerfield Beach, Fla.) · 2026Article
- Review of GPU-based Monte Carlo simulation platforms for transmission and emission tomography in medicine.Physics in medicine and biology · 2025Review
- High-performance dual-ended SiPM readout for TOF-PET with BGO and LYSO:Ce.IEEE transactions on radiation and plasma medical sciences · 2025Article
- Dual-ended readout TOF-DOI PET detectors based on 3.2 mm and 1.6 mm pitch LYSO arrays.EJNMMI physics · 2025Article
- Heterogeneous Tapped Delay-Line Time-to-Digital Converter on Artix-7 FPGA.Sensors (Basel, Switzerland) · 2025Article
- A new design to improve time resolution in a time of flight brain PET using dual layer offset scintillator crystals.Scientific reports · 2025Article
- Ultrafast Superradiant Scintillation from Isolated Weakly Confined Perovskite Nanocrystals.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- End-to-end design of multicolor scintillators for enhanced energy resolution in X-ray imaging.Light, science & applications · 2025Article
- A deep learning method for the recovery of standard-dose imaging quality from ultra-low-dose PET on wavelet domain.European journal of nuclear medicine and molecular imaging · 2025Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 14 institutions in 11 countries.
Funding
Abstract
Since the seventies, positron emission tomography (PET) has become an invaluable medical molecular imaging modality with an unprecedented sensitivity at the picomolar level, especially for cancer diagnosis and the monitoring of its response to therapy. More recently, its combination with x-ray computed tomography (CT) or magnetic resonance (MR) has added high precision anatomic information in fused PET/CT and PET/MR images, thus compensating for the modest intrinsic spatial resolution of PET. Nevertheless, a number of medical challenges call for further improvements in PET sensitivity. These concern in particular new treatment opportunities in the context personalized (also called precision) medicine, such as the need to dynamically track a small number of cells in cancer immunotherapy or stem cells for tissue repair procedures. A better signal-to-noise ratio (SNR) in the image would allow detecting smaller size tumours together with a better staging of the patients, thus increasing the chances of putting cancer in complete remission. Moreover, there is an increasing demand for reducing the radioactive doses injected to the patients without impairing image quality. There are three ways to improve PET scanner sensitivity: improving detector efficiency, increasing geometrical acceptance of the imaging device and pushing the timing performance of the detectors. Currently, some pre-localization of the electron-positron annihilation along a line-of-response (LOR) given by the detection of a pair of annihilation photons is provided by the detection of the time difference between the two photons, also known as the time-of-flight (TOF) difference of the photons, whose accuracy is given by the coincidence time resolution (CTR). A CTR of about 10 picoseconds FWHM will ultimately allow to obtain a direct 3D volume representation of the activity distribution of a positron emitting radiopharmaceutical, at the millimetre level, thus introducing a quantum leap in PET imaging and quantification and fostering more frequent use of
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.