ArticleCell reports2020
Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis.
Article in Cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transcriptomic Studies of Antidepressant Action in Rodent Models of Depression: A First Meta-Analysis.International journal of molecular sciences · 2022Pooled it
- The ventral hippocampus: computations, circuits and functions.Nature reviews. Neuroscience · 2026Review
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.Hippocampus · 2026Article
- GABAergic subiculum-medial entorhinal projection in mice and rats.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Essential function of Nr4a2 in subicular development and social novelty.Journal of advanced research · 2026Article
- Article
- Fibronectin1-Expressing Subicular Circuits Selectively Govern the Retrieval of Novel Object Recognition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Mapping Projectome Heterogeneity of Subiculum Neuron Cell Types.bioRxiv : the preprint server for biology · 2026Article
- Top-down regulation of ingestive behavior fragmentation.bioRxiv : the preprint server for biology · 2026Article
- Non-Canonical Subiculum Circuit Organization and Function.Hippocampus · 2026Review
- A molecularly anchored spatial transcriptomic framework for precise CA1-subiculum parcellation and region-resolved analysis in Alzheimer's disease.GigaScience · 2026Article
- Mapping prefrontal afferents along development.Frontiers in neuroscience · 2026Article
- Hippocampome.org, a resource for subicular neuron types and beyond.bioRxiv : the preprint server for biology · 2025Article
- Ventral subicular pyramidal neurons contribute to epileptogenesis via anterior thalamic circuit.Communications biology · 2025Article
- Data-driven fine-grained region discovery in the mouse brain with transformers.Nature communications · 2025Article
- Hippocampal pyramidal cells of the CA1 region are not a major target of the thalamic nucleus reuniens.PLoS biology · 2025Article
- An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus.Nature neuroscience · 2025Article
- Hippocampal architecture viewed through the eyes of methodological development.Anatomical science international · 2025Review
- Prolonged exposure to food odors suppresses feeding via an olfactory bulb-to-hypothalamus circuit.Nature communications · 2025Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Subicular regions play important roles in spatial processing and many cognitive functions, and these are mainly attributed to the subiculum (Sub) rather than the prosubiculum (PS). Using single-cell RNA sequencing, we identify 27 transcriptomic cell types residing in sub-domains of the Sub and PS. Based on in situ expression of reliable transcriptomic markers, the precise boundaries of the Sub and PS are consistently defined along the dorsoventral axis. Using these borders to evaluate Cre-line specificity and tracer injections, we find bona fide Sub projections topographically to structures important for spatial processing and navigation. In contrast, the PS sends its outputs to widespread brain regions crucial for motivation, emotion, reward, stress, anxiety, and fear. The Sub and PS, respectively, dominate dorsal and ventral subicular regions and receive different afferents. These results reveal two molecularly and anatomically distinct circuits centered in the Sub and PS, respectively, providing a consistent explanation for historical data and a clearer foundation for future studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.