Evidence map›Paper›PMID 32433891›Full record

ArticleCirculation. Arrhythmia and electrophysiology2020

Triggered Ca

Georg Gussak, William Marszalec, Shin Yoo, Rishi Modi, Caitlin O'Callaghan, Gary L Aistrup, Jonathan M Cordeiro, Robert Goodrow, Giedrius Kanaporis, Lothar A Blatter and 5 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Proteolytic degradation of atrial sarcomere proteins underlies contractile defects in atrial fibrillation.American journal of physiology. Heart and circulatory physiology · 2024
    Article
  3. Therapeutic advances in atrial fibrillation based on animal models.Journal of Zhejiang University. Science. B · 2024
    Review
  4. Article
  5. Antiarrhythmic and Inotropic Effects of Selective NaInternational journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Georg GussakThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
William MarszalecThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Shin YooThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Rishi ModiThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Caitlin O'CallaghanThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Gary L AistrupThe Masonic Medical Research Institute, Utica, NY (G.L.A., J.M.C., R.G.).
Jonathan M CordeiroThe Masonic Medical Research Institute, Utica, NY (G.L.A., J.M.C., R.G.).
Robert GoodrowThe Masonic Medical Research Institute, Utica, NY (G.L.A., J.M.C., R.G.).
Giedrius KanaporisDepartment of Physiology and Biophysics, Rush University Medical School, Chicago, IL (G.K., L.A.B.).
Lothar A BlatterDepartment of Physiology and Biophysics, Rush University Medical School, Chicago, IL (G.K., L.A.B.).
Yohannes ShiferawDepartment of Physics, California State University, Northridge (Y.S.).
Rishi AroraThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Junlan ZhouThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Amy R BurrellThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
J Andrew WasserstromThe Feinberg Cardiovascular and Renal Research Institute and Department of Medicine (Cardiology), Northwestern Feinberg School of Medicine, Chicago, IL (G.G., W.M., S.Y., R.M., C.O., R.A., J.Z., A.R.B., J.A.W.).
Northwestern University · USMasonic Medical Research Laboratory · USRush University Medical Center · USCalifornia State University, Northridge · US

Funding

Limiting Pathological Calcium Induced Calcium Release in HeartR01HL057832 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI FILL, MICHAEL, GILLESPIE, DIRK · 1997 to 2024
$9.0M
Atrial arrhythmias and Ca2+ waves in HF: simulation and experimental studiesR01HL119095 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHIFERAW, YOHANNES, WASSERSTROM, JOHN ANDREW · 2014 to 2018
$3.0M
Pathophysiological Significance of Atrial Fibrillation Electrogram PatternsR01HL125881 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2015 to 2019
$2.4M
Oxidative stress contributes to atrial fibrillation by causing remodeling of the autonomic nervous systemR01HL140061 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ARORA, RISHI · 2018 to 2021
$2.3M
KITP Interdisciplinary Biology InitiativeR25GM067110 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI SHRAIMAN, BORIS I · 2003 to 2018
$1.8M
Pathophysiological Regulation of Atrial Alternans and Atrial FibrillationR01HL132871 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BANACH, KATHRIN, BLATTER, LOTHAR A · 2017 to 2020
$1.6M
Pathophysiological Regulation of Atrial Myocyte Excitation-Contraction Coupling and Calcium SignalingR01HL134781 · NHLBI · RUSH UNIVERSITY MEDICAL CENTER · PI BLATTER, LOTHAR A · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL057832NHLBI NIH HHS R01 HL119095NHLBI NIH HHS R01 HL125881NHLBI NIH HHS R01 HL132871NHLBI NIH HHS R01 HL134781NHLBI NIH HHS R01 HL140061NIGMS NIH HHS R25 GM067110
6 · The paper itself

Abstract

backgroundWe have identified a novel form of abnormal Ca

methodsSimultaneous recordings of intracellular Ca

resultsAt 3.3 to 5 Hz, TCWs occurred during the AP and often outlasted several AP cycles. Maximum diastolic potential was reduced, and AP duration was significantly prolonged during TCWs. All electrophysiological responses to TCWs were abolished by SEA0400 and ORM10103, indicating that Na-Ca exchange current caused depolarization. The time constant of recovery from inactivation of Ca

conclusionsTriggered Ca

Indexed as

Action PotentialsCalcium SignalingHeart RateAnimalsArrhythmias, CardiacComputer SimulationDiastoleDogsFemaleMaleModels, CardiovascularMyocytes, CardiacSodium-Calcium ExchangerTime FactorsSodium-Calcium Exchangeraction potentialatrial fibrillationcalcium channelcomputer simulationdiastole

Identifiers

PMID32433891
PMCPMC7340345
OpenAlexW3026926572

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.