Evidence map›Paper›PMID 32433882›Full record

ArticleAnalytical chemistry2020

Sub-zeptomole Detection of Biomarker Proteins Using a Microfluidic Immunoarray with Nanostructured Sensors.

Lasangi Dhanapala, Abby L Jones, Patricia Czarnecki, James F Rusling

Abstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Multiplexed electrochemical assays for clinical applications.Current opinion in electrochemistry · 2023
    Article
  6. Review
  7. Modified ELISA for Ultrasensitive Diagnosis.Journal of clinical medicine · 2021
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Lasangi DhanapalaDepartment of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269, United States.
Abby L JonesDepartment of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269, United States.
Patricia CzarneckiDepartment of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269, United States.
James F RuslingDepartment of Chemistry, University of Connecticut, 55 North Eagleville Road, Storrs, Connecticut 06269, United States.ORCID 0000-0002-6117-3306

Funding

Protein Biomarker Arrays for Personalized Treatment of Prostate CancerR01EB016707 · NIBIB · UNIVERSITY OF CONNECTICUT STORRS · PI RUSLING, JAMES F. · 2014 to 2017
$1.4M
NIBIB NIH HHS R01 EB016707
6 · The paper itself

Abstract

We report here a low-cost electrochemical immunoarray with unprecedented sensitivity in the sub-zeptomole range with up to 5 log-decades dynamic range for accurate, multiplexed protein determinations. The microfluidic array features eight carbon sensors coated with a dense layer of 5 nm gold-nanoparticles derivatized with primary antibodies. Analyte proteins are captured by secondary antibody-poly-HPR (horseradish peroxidase) bioconjugates containing 400 HRP enzyme labels, with amplified amperometric peaks developed using H

Indexed as

Biosensing TechniquesElectrochemical TechniquesImmunoassayLab-On-A-Chip DevicesBiomarkers, TumorHumansInsulin-Like Growth Factor IMaleNanostructuresProstate-Specific AntigenProstatic NeoplasmsTranscriptional Regulator ERGVascular Endothelial Growth Factor DBiomarkers, TumorERG protein, humanIGF1 protein, humanInsulin-Like Growth Factor IProstate-Specific AntigenTranscriptional Regulator ERGVascular Endothelial Growth Factor DVEGFD protein, human

Identifiers

PMID32433882
PMCPMC7509851

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.