ArticlePloS one2020
Effect of physical stimulation (gingival massage) on age-related changes in gingival microcirculation.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 10 citations in OpenAlex.
- The Psychosocial Impact on Gingival Aesthetics Questionnaire (PIGAQ): The Effect of Sociodemographic Variables on Results in a Spanish Adult Population. An Observational and Cross-Sectional Study.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2025Observational
- Optimization of Tuina rolling manipulation parameters to promote blood circulation using a circulatory orthogonal experiment.Journal of physical therapy science · 2024Article
- The Effect of Changing the Toothbrush on the Marginal Gingiva Microcirculation in the Adolescent Population-A Laser Doppler Flowmetry Assessment.Diagnostics (Basel, Switzerland) · 2022Article
- Oral hygiene practices in the pandemic- Evidence-based discussion of 8 common issues.Journal of family medicine and primary care · 2022Article
- Revisiting the vascularity of the keratinized gingiva in the maxillary esthetic zone.BMC oral health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The decline in circulatory function with aging may be alleviated by a combination of gingival massage (physical stimulation) and mechanical cleaning. Several studies have reported the systemic effect of physical stimulation on various parts of the body, including its therapeutic effect on pain in the neck and shoulders that becomes evident with age, and improvement in blood circulation. In contrast, few studies have reported on the changes in gingival microcirculation induced by gingival massage, while no previous study has evaluated the effect of gingival microcirculation on age-related changes in the hemodynamics of the oral cavity. This study aimed to investigate how gingival massage affects age-related changes in gingival microcirculation. Male Wistar rats (7-week, 6-month and 1-year old) were prepared for a gingival massage group and a control group. Mechanical stimulation was applied on the maxillary molar gingiva for 5 seconds twice a week for 4 weeks. Subsequently, gingival reactive hyperemia was measured using a laser Doppler flowmeter. In addition, morphological analyses were also performed by hematoxylin and eosin and Indian ink staining and a vascular resin cast model. Base Flow, maximum response (Peak), and time required for the maximum response to halve (T1/2) were reduced in 1-year-old rats compared with the other age groups. In the mechanical stimulated group, T1/2 was increased in 7-week, 6-month, and 1-year-old rats, and total blood flow (Mass) was increased in 6-month and 1-year-old rats. In addition, clear blood vessel networks and loop-like revascularization were only observed in the mechanical stimulated group. Changes in age-related decline in gingival microcirculatory function and vascular construction were reported in this study, and the results suggested that gingival massage activates both the functional and morphological aspects of gingival microcirculation and may be effective for maintaining oral health.
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