ArticleInternational journal of obesity (2005)2020
Inflammatory agents partially explain associations between cortical thickness, surface area, and body mass in adolescents and young adulthood.
Article in International journal of obesity (2005), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 27 citations in OpenAlex.
- Sex-related difference of subcortical gray matter volume associated with crystallized intelligence in young adults with obesity.Biology of sex differences · 2026Article
- Plasma Inflammatory Biomarkers Lack Strong Association With Cognitive Outcomes Among Young Adults With Perinatal HIV Exposure and/or Acquisition.Journal of acquired immune deficiency syndromes (1999) · 2026Article
- The effect of weight loss on brain age in schizophrenia spectrum disorders.PLOS mental health · 2025Article
- Inhibitory control mediates the association between body mass index and math performance in children: A cross-sectional study.PloS one · 2024Article
- Higher Levels of C-reactive Protein Are Associated With Higher Cortical Surface Area and Lower Cortical Thickness in Youth With Bipolar Disorder.The international journal of neuropsychopharmacology · 2023Article
- Biobehavioral susceptibility for obesity in childhood: Behavioral, genetic and neuroimaging studies of appetite.Physiology & behavior · 2023Review
- Beyond BMI: cardiometabolic measures as predictors of impulsivity and white matter changes in adolescents.Brain structure & function · 2023Article
- Controlling the Impact ofMedicina (Kaunas, Lithuania) · 2023Article
- Morphology of the prefrontal cortex predicts body composition in early adolescence: cognitive mediators and environmental moderators in the ABCD Study.Social cognitive and affective neuroscience · 2023Article
- Gene Expression Changes of Murine Cortex Homeostasis in Response to Sleep Deprivation Hint Dysregulated Aging-like Transcriptional Responses.Brain sciences · 2022Article
- Effects of severe obesity and sleeve gastrectomy on cortical thickness in adolescents.Obesity (Silver Spring, Md.) · 2021Article
- The Impact of Restrictive and Non-restrictive Dietary Weight Loss Interventions on Neurobehavioral Factors Related to Body Weight Control: the Gaps and Challenges.Current obesity reports · 2021Review
- Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness.JAMA psychiatry · 2021Article
- Restrained Eating Is Associated with Lower Cortical Thickness in the Inferior Frontal Gyrus in Adolescents.Brain sciences · 2021Article
- Inflammation and Cognition in Children and Adolescents: A Call for Action.Frontiers in pediatrics · 2020Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesExcessive body mass index (BMI) has been linked to a low-grade chronic inflammation state. Unhealthy BMI has also been related to neuroanatomical changes in adults. Research in adolescents is relatively limited and has produced conflicting results. This study aims to address the relationship between BMI and adolescents' brain structure as well as to test the role that inflammatory adipose-related agents might have over this putative link.
methodsWe studied structural MRI and serum levels of interleukin-6, tumor necrosis factor alpha (TNF-α), C-reactive protein and fibrinogen in 65 adolescents (aged 12-21 years). Relationships between BMI, cortical thickness and surface area were tested with a vertex-wise analysis. Subsequently, we used backward multiple linear regression models to explore the influence of inflammatory parameters in each brain-altered area.
resultsWe found a negative association between cortical thickness and BMI in the left lateral occipital cortex (LOC) and the right precentral gyrus as well as a positive relationship between surface area and BMI in the left rostral middle frontal gyrus and the right superior frontal gyrus. In addition, we found that higher fibrinogen serum concentrations were related to thinning within the left LOC (β = -0.45, p < 0.001), while higher serum levels of TNF-α were associated to a greater surface area in the right superior frontal gyrus (β = 0.32, p = 0.045). Besides, we have also identified a trend that negatively correlates the cortical thickness of the left fusiform gyrus with the increases in BMI. It was also associated to fibrinogen (β = -0.33, p = 0.035).
conclusionsThese results suggest that adolescents' body mass increases are related with brain abnormalities in areas that could play a relevant role in some aspects of feeding behavior. Likewise, we have evidenced that these cortical changes were partially explained by inflammatory agents such as fibrinogen and TNF-α.
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