Evidence map›Paper›PMID 32433555›Full record

Observational studyScientific reports2020

IRE1α and IGF signaling predict resistance to an endoplasmic reticulum stress-inducing drug in glioblastoma cells.

Jeffrey J Rodvold, Su Xian, Julia Nussbacher, Brian Tsui, T Cameron Waller, Stephen C Searles, Alyssa Lew, Pengfei Jiang, Ivan Babic, Natsuko Nomura and 4 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

Jeffrey J RodvoldThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Su XianDivision of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-8295-876X
Julia NussbacherDepartment of Cellular and Molecular Medicine, University of California, San Diego, La Jolla, California, USA.
Brian TsuiDivision of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0001-8017-5895
T Cameron WallerDivision of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA.ORCID http://orcid.org/0000-0002-0313-6646
Stephen C SearlesThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Alyssa LewThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA.
Pengfei JiangDepartment of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Ivan BabicDepartment of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Natsuko NomuraDepartment of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA.
Jonathan H LinDepartment of Pathology, Stanford University, Palo Alto, CA, 94305, USA.ORCID http://orcid.org/0000-0002-7438-6941
Santosh KesariDepartment of Translational Neurosciences and Neurotherapeutics, John Wayne Cancer Institute/Pacific Neuroscience Institute, 2200 Santa Monica Boulevard, Santa Monica, CA, 90404, USA. kesaris@jwci.org.ORCID http://orcid.org/0000-0003-3772-6000
Hannah CarterDivision of Medical Genetics, Department of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. hkcarter@ucsd.edu.ORCID http://orcid.org/0000-0002-1729-2463
Maurizio ZanettiThe Laboratory of Immunology, Department of Medicine and Moores Cancer Center, University of California, San Diego 9500 Gilman Drive, La Jolla, CA, 92093-0815, USA. mzanetti@ucsd.edu.
University of California San Diego · USSaint John's Health Center · USPalo Alto University · US

Funding

UCSD Cancer Center Training Program in Drug DevelopmentT32CA121938 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Michael Bouvet, Dwayne G. Stupack · 2006 to 2026
$10.3M
Protein Homeostasis and Proteotoxicity MechanismsR01NS088485 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIN, JONATHAN · 2015 to 2024
$3.0M
Molecular Pathology of AchromatopsiaR01EY027335 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LIN, JONATHAN · 2017 to 2019
$1.2M
Phase 2 Study of Vascular-Targeted Prodrug (G-202) for the Treatment of Recurrent GlioblastomaR01FD005077 · FDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KESARI, SANTOSH, ZANETTI, MAURIZIO · 2015 to 2017
$1.1M
BLRD VA I01 BX002284FDA HHS R01 FD005077NCI NIH HHS T32 CA121938NEI NIH HHS R01 EY027335NINDS NIH HHS R01 NS088485
6 · The paper itself

Abstract

To date current therapies of glioblastoma multiforme (GBM) are largely ineffective. The induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential new therapeutic strategy. Here we tested 12ADT, a sarcoendoplasmic reticulum Ca

Indexed as

AdultApoptosisBrainBrain NeoplasmsCell Line, TumorDrug Resistance, NeoplasmEndoplasmic Reticulum StressEndoribonucleasesGene Expression Regulation, NeoplasticGlioblastomaHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 5Primary Cell CultureProgression-Free SurvivalProtein Serine-Threonine KinasesEndoribonucleasesERN1 protein, humanIGFBP3 protein, humanIGFBP5 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor Binding Protein 5Protein Serine-Threonine KinasesSarcoplasmic Reticulum Calcium-Transporting ATPasesThapsigargin

Identifiers

PMID32433555
PMCPMC7239929
OpenAlexW3026132372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.