Evidence map›Paper›PMID 32433503›Full record

ArticleScientific reports2020

PolyRad - Protection Against Free Radical Damage.

Hannah Kim, Yin Tse, Andrew Webb, Ethan Mudd, Muhammad Raisul Abedin, Melanie Mormile, Subhadeep Dutta, Kaushal Rege, Sutapa Barua

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Hannah Kim *Department of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Yin Tse *Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Andrew Webb *Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Ethan Mudd *Department of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Muhammad Raisul AbedinDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Melanie MormileDepartment of Biological Sciences, Missouri University of Science and Technology, Rolla, MO, 65409, USA.
Subhadeep DuttaSchool of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Kaushal RegeChemical Engineering, School for Engineering of Matter, Transport and Energy, Arizona State University, Tempe, AZ, 85287, USA.
Sutapa BaruaDepartment of Chemical and Biochemical Engineering, Missouri University of Science and Technology, Rolla, MO, 65409, USA. baruas@mst.edu.
Missouri University of Science and Technology · USArizona State University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The effects of elevated levels of radiation contribute to the instability of pharmaceutical formulations in space compared to those on earth. Existing technologies are ineffective at maintaining the therapeutic efficacies of drugs in space. Thus, there is an urgent need to develop novel space-hardy formulations for preserving the stability and efficacy of drug formulations. This work aims to develop a novel approach for the protection of space pharmaceutical drug molecules from the radiation-induced damage to help extend or at least preserve their structural integrity and potency. To achieve this, free radical scavenging antioxidant, Trolox was conjugated on the surface of poly-lactic-co-glycolic acid (PLGA) nanoparticles for the protection of a candidate drug, melatonin that is used as a sleep aid medication in International Space Station (ISS). Melatonin-PLGA-PLL-Trolox nanoparticle as named as PolyRad was synthesized employing single oil in water (o/w) emulsion solvent evaporation method. PolyRad is spherical in shape and has an average diameter of ~600 nm with a low polydispersity index of 0.2. PolyRad and free melatonin (control) were irradiated by UV light after being exposed to a strong oxidant, hydrogen peroxide (H

Identifiers

PMID32433503
PMCPMC7239908
OpenAlexW3028292825

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.