Evidence map›Paper›PMID 32433502›Full record

ArticleScientific reports2020

Microscopy analysis of Zika virus morphogenesis in mammalian cells.

Lucio Ayres Caldas, Renata Campos Azevedo, Jerson Lima da Silva, Wanderley de Souza

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lucio Ayres CaldasLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro. Av. Carlos Chagas Filho 373, Prédio CCS, Bloco C, subsolo, CEP:21941902, Cidade Universitária, Rio de Janeiro, RJ, Brazil. lucio@biof.ufrj.br.
Renata Campos AzevedoLaboratório de Interação Vírus-Célula, Instituto de Microbiologia Professor Paulo de Góes, Universidade Federal do Rio de Janeiro. Av. Carlos Chagas Filho 373, Prédio CCS, Bloco I, subsolo, CEP:21941902, Cidade Universitária, Rio de Janeiro, RJ, Brazil.
Jerson Lima da SilvaInstituto de Bioquímica Médica Leopoldo de Meis, Laboratório de Termodinâmica de Proteínas e Estruturas Virais Gregório Weber, Universidade Federal do Rio de Janeiro. Av. Carlos Chagas Filho 373, Prédio CCS, Bloco E, sala 10, Cidade Universitária, CEP:21941902, Rio de Janeiro, RJ, Brazil.
Wanderley de SouzaLaboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro. Av. Carlos Chagas Filho 373, Prédio CCS, Bloco C, subsolo, CEP:21941902, Cidade Universitária, Rio de Janeiro, RJ, Brazil.
Universidade Federal do Rio de Janeiro · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zika virus (ZIKV) is an arbovirus that recently emerged in the Americas as an important pathogen mainly because of its expanded pathogenesis, and elevated tropism for neuronal cells, transposition across the placental barrier, and replication in reproductive tract cells. Thus, transmission modes are eventually independent of an invertebrate vector, which is an atypical behavior for the flavivirus genus and indicates the need to study the replication of this virus in different cell types. Although ZIKV became a target for public health programs, the interaction of this flavivirus with the infected cell is still poorly understood. Herein, we analyzed the main stages of virus morphogenesis in mammalian cells, from establishment of the viroplasm-like zone to viral release from infected cells, using super-resolution fluorescence microscopy and electron microscopy. In addition, we compared this with other host cell types and other members of the Flaviviridae family that present a similar dynamic.

Indexed as

Host Microbial InteractionsMorphogenesisAedesAnimalsCell LineChlorocebus aethiopsElectron Microscope TomographyEpithelial CellsHumansMacaca mulattaMicroscopy, FluorescenceVirus ReleaseVirus ReplicationZika VirusZika Virus Infection

Identifiers

PMID32433502
PMCPMC7239924
OpenAlexW3027805663

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.