Evidence map›Paper›PMID 32433478›Full record

ArticleScientific reports2020

Infarct in new territory after endovascular stroke treatment: A diffusion-weighted imaging study.

Johannes Kaesmacher, Christoph Kurmann, Noel Jungi, Philipe Breiding, Matthias F Lang, Raphael Meier, Tomas Dobrocky, Eike Piechowiak, Felix Zibold, Sebastian Bellwald and 8 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Infarct in a new territory: Risk factors and outcomes: A comparative meta-analysis.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 2 countries.

Johannes Kaesmacher *University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Christoph Kurmann *University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Noel JungiDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Philipe BreidingUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Matthias F LangUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Raphael MeierSupport Center for Advanced Neuroimaging - Institute for Diagnostic and Inter-ventional Neuroradiology, University Hospital Inselspital and University of Bern, Bern, Switzerland.
Tomas DobrockyUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Eike PiechowiakUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Felix ZiboldUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Sebastian BellwaldDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Thomas R MeinelDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.ORCID http://orcid.org/0000-0002-0647-9273
Mirjam R HeldnerDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Pasquale MordasiniUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Marcel ArnoldDepartment of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Pascal J MosimannUniversity Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Mayank GoyalDepartment of Diagnostic Imaging, University of Calgary, Calgary, Alberta, Canada.
Jan Gralla *University Institute of Diagnostic and Interventional Neuroradiology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland.
Urs Fischer *Department of Neurology, University Hospital Bern, Inselspital, University of Bern, Bern, Switzerland. urs.fischer@insel.ch.
University of Bern · CHUniversity of Calgary · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Data on infarcts in new territory (INT) in patients undergoing endovascular stroke treatment for acute large-vessel occlusions are sparse. Aim of this study was to assess the prevalence, risk factors, and clinical relevance of INT. For this purpose, all patients in a single-center prospective registry who underwent endovascular stroke treatment and received pre- and post-interventional diffusion-weighted imaging were included (N = 259). Using an established scoring system, INT were classified according to size (I-III, ≤2 mm, >2 mm ≤20 mm, >20 mm) and likelihood of being related to the intervention (A, high likelihood; B, low likelihood). Additionally, a new type of infarct, that occurred in a territory distal to the occlusion, but was initially not hypoperfused, was defined as an infarct in initially not hypoperfused territory (IINHT). A total of 180 INT and 38 IINHT were observed in 32.8% (N = 85/259) of patients. In most patients, INT were angiographically occult (90.2%), and 13 patients had INT/IINHT larger than 2 cm (type III). Absence of protection during stent-retrieval and a cardio-embolic stroke origin were associated with higher incidence of INT/IINHT, whereas pretreatment with IV tPA showed no association, even when different bolus timing was considered. INT/IINHT were associated with lower rates of functional independence with increasing size type after adjusting for confounders (adjusted Odds Ratio per size group increase 0.63, 95% confidence interval 0.46-0.86). In conclusion, INT and IINHT are not rare, are associated with poor outcome with increasing size, and they may serve as a surrogate endpoint for safety evaluation of new devices and endovascular techniques. Further research on associated factors is warranted.

Indexed as

AgedBrainBrain InfarctionDiffusion Magnetic Resonance ImagingEndovascular ProceduresFemaleFollow-Up StudiesHumansMaleMiddle AgedPostoperative ComplicationsPostoperative PeriodPreoperative CareProspective StudiesRegistriesRetrospective Studies

Identifiers

PMID32433478
PMCPMC7239894
OpenAlexW3027372424

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.