ArticleThe Pediatric infectious disease journal2020
Steep Declines in Pediatric AIDS Mortality in South Africa, Despite Poor Progress Toward Pediatric Diagnosis and Treatment Targets.
Article in The Pediatric infectious disease journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HIV care cascade of adolescents and young adults in sub-Saharan Africa: a systematic review and meta-analysis.BMJ open · 2026Pooled it
- Gastrointestinal and respiratory morbidity when introducing eggs as complementary food: a randomised controlled trial in South African infants.Scientific reports · 2024Trial
- HIV/AIDS Mortality in the Eastern Cape Province of South Africa, 2000-2023: Trends, Age-Sex Composition, and a Persistent Provincial Burden.Tropical medicine and infectious disease · 2026Article
- High Incidence of Tuberculosis in Young Children Living With HIV in the Western Cape, South Africa.Journal of acquired immune deficiency syndromes (1999) · 2025Article
- Comparison of infant feeding practices by maternal HIV status, and associated factors, in a rural district, South Africa 2019.International breastfeeding journal · 2025Article
- Mother-child dyads living with HIV in the Western Cape, South Africa: Undetectable = Undetectable?Journal of the International AIDS Society · 2025Article
- The effect of STI screening during pregnancy on vertical transmission of HIV and adverse pregnancy outcomes in South Africa: a modelling study.Journal of the International AIDS Society · 2025Article
- Mortality trends and causes of death in a South African hospital complex pre- and during COVID-19.Southern African journal of infectious diseases · 2025Article
- HIV-associated rectovaginal fistulae in children: a single-centre retrospective study in the antiretroviral era.Pediatric surgery international · 2024Article
- The impact of antiretroviral treatment and child-focused unconditional cash transfers on child mortality.SSM - population health · 2024Article
- Viral load non-suppression among adolescents and youth living with HIV in South Africa.Southern African journal of infectious diseases · 2024Article
- Eliminating Vertical Transmission of HIV in South Africa: Establishing a Baseline for the Global Alliance to End AIDS in Children.Diagnostics (Basel, Switzerland) · 2023Article
- The impact of child mortality on fertility in South Africa: Do child support grants and antiretroviral treatment matter?PloS one · 2023Article
- Article
- Prevalence of undiagnosed HIV among children in South Africa, Côte d'Ivoire and Zimbabwe: a model-based analysis to inform paediatric HIV screening programmes.Journal of the International AIDS Society · 2022Article
- The importance of assessing and addressing mental health barriers to PrEP use during pregnancy and postpartum in sub-Saharan Africa: state of the science and research priorities.Journal of the International AIDS Society · 2022Article
- Cost-effectiveness of Routine Provider-Initiated Testing and Counseling for Children With Undiagnosed HIV in South Africa.Open forum infectious diseases · 2022Article
- The next generation: Pregnancy in adolescents and women living with perinatally acquired HIV in South Africa.South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · 2021Article
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8 authors.
Funding
Abstract
backgroundFew attempts have been made to monitor progress toward HIV diagnosis and antiretroviral treatment (ART) coverage targets in children, and the impact that ART and prevention of mother-to-child transmission (PMTCT) programs have had on pediatric HIV incidence and mortality.
methodsA multiparameter evidence synthesis approach was adopted to integrate South African pediatric HIV data sources. A previously developed model of HIV in South Africa was calibrated to household survey HIV prevalence data, routine antibody testing data, data on numbers and ages of children on ART, vital registration data and data on HIV diagnosis at death. The impact of ART and PMTCT was estimated by comparing validated model outputs against model predictions of the trends that would have been expected in the absence of ART and PMTCT.
resultsBy mid-2018, the model estimated that 75.2% (95% CI: 73.9%-76.8%) of HIV-positive children were diagnosed, substantially lower than the corresponding estimates in HIV-positive adults (91.0%). ART coverage in children in 2018 (51.2%, 95% CI: 49.4%-52.7%) was also lower than that in adults (62.0%). In 2017-2018, the numbers of new cases of mother-to-child transmission and pediatric AIDS deaths were reduced by 84% and 94%, respectively, relative to what would have been expected in the absence of interventions, but reductions in mortality were driven largely by PMTCT.
conclusionsAlthough levels of AIDS mortality in children have declined dramatically in South Africa, this has mostly been due to successful PMTCT programs, and progress toward the 90-90-90 targets appears relatively poor when compared with that in adults.
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