ArticleIET nanobiotechnology2020
Antibacterial activity of SPIONs versus ferrous and ferric ions under aerobic and anaerobic conditions: a preliminary mechanism study.
Article in IET nanobiotechnology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 63 citations in OpenAlex.
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- Garlic Extract-Mediated SPIONs-Incorporated Nanohydrogel for Enhanced Wound Healing Potential.Current drug delivery · 2026Article
- Surface Properties of Coatings Based on Iron Amino-Functionalized Oxides Deposited on DH 36 Steel Plates for Shipbuilding.Nanomaterials (Basel, Switzerland) · 2025Article
- Iron Oxide Nanoparticles as Promising Antibacterial Agents of New Generation.Nanomaterials (Basel, Switzerland) · 2024Review
- Antimicrobial activity of metal-based nanoparticles: a mini-review.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024Review
- Salvianolic acid A alleviates HScientific reports · 2024Article
- Bacterial nanotechnology as a paradigm in targeted cancer therapeutic delivery and immunotherapy.Microsystems & nanoengineering · 2024Review
- Pharmacotechnical aspects of a stable probiotic formulation toward multidrug-resistance antibacterial activity: design and quality control.BMC complementary medicine and therapies · 2023Article
- Bringing resistance modulation to methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) strains using a quaternary ammonium compound coupled with zinc oxide nanoparticles.World journal of microbiology & biotechnology · 2023Article
- Effect of different physical factors on the synthesis of spherical gold nanoparticles towards cost-effective biomedical applications.IET nanobiotechnology · 2023Article
- Biosynthesis and Antimicrobial Evaluation of Zinc Oxide Nanoparticles UsingMaterials (Basel, Switzerland) · 2023Article
- Metal Nanoparticles to CombatMicroorganisms · 2023Review
- Exploring the potential and safety of quantum dots in allergy diagnostics.Microsystems & nanoengineering · 2023Review
- TiOMaterials (Basel, Switzerland) · 2022Article
- Review
- Mechanisms of Metallic Nanomaterials to Induce an Antibacterial Effect.Current topics in medicinal chemistry · 2022Review
- Antibacterial approaches in tissue engineering using metal ions and nanoparticles: From mechanisms to applications.Bioactive materials · 2021Review
- Exploring the bone sparing effects of postbiotics in the post-menopausal rat model.BMC complementary medicine and therapies · 2021Article
- A Review on Health Benefits ofEvidence-based complementary and alternative medicine : eCAM · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In modern medicine, major attention has been paid to superparamagnetic iron oxide nanoparticles (SPIONs). Recent studies have shown the antibacterial properties of SPIONs against some Gram-positive and Gram-negative bacterial strains. These nanoparticles (NPs) can bind to bacterial membranes via hydrophobic or electrostatic interactions and pass through cell barriers. In this study, the authors evaluated the antibacterial activity of magnetic NPs in comparison with ferrous and ferric ions. The level of reactive oxygen species (ROS) in the treated Staphylococcus aureus and Escherichia coli bacteria were directly measured by fluorometric detection. The results showed that iron ions and SPIONs had significant dependent antimicrobial activities. SPIONs showed greater inhibitory effects than ferrous and ferric ions against the growth of treated bacterial strains under anaerobic conditions, while in aerobic conditions, ferrous showed the strongest antibacterial activity. In anaerobic conditions, they observed the greatest ROS formation and lowest minimum inhibitory concentration in the SPION-treated group in comparison with the other groups. It seems that the release of iron ions from SPIONs and subsequent activation of ROS pathway are the main antibacterial mechanisms of action. Nevertheless, the greater antibacterial effect of SPIONs in anaerobic conditions represents other mechanisms involved in the antibacterial activity of these NPs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.