Evidence map›Paper›PMID 32432932›Full record

ArticleAmerican journal of physiology. Cell physiology2020

Thermal injury initiates pervasive fibrogenesis in skeletal muscle.

Camille R Brightwell, Madeline E Hanson, Amina El Ayadi, Anesh Prasai, Ye Wang, Celeste C Finnerty, Christopher S Fry

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 10 citations in OpenAlex.

  1. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Article
  3. Myonuclear Dynamics After Skeletal Muscle Surgical Injury.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Camille R BrightwellCell Biology Graduate Program, University of Texas Medical Branch, Galveston, Texas.
Madeline E HansonDepartment of Nutrition and Metabolism, University of Texas Medical Branch, Galveston, Texas.
Amina El AyadiDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Anesh PrasaiDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Ye WangDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Celeste C FinnertyDepartment of Surgery, University of Texas Medical Branch, Galveston, Texas.
Christopher S FryDepartment of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, Kentucky.ORCID 0000-0002-4207-6594
Shriners Hospitals for Children - Galveston · USUniversity of Kentucky · USThe University of Texas Medical Branch at Galveston · US

Funding

HEALTH OF OLDER MINORITIEST32AG000270 · NIA · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Brian Gregory Downer, NEIL MEHTA · 1999 to 2026
$5.2M
Myostatin Alters Muscle Composition as The Result of an ACL InjuryR01AR072061 · NIAMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FRY, CHRISTOPHER · 2018 to 2023
$2.2M
Effects of Chronic Catecholamine Exposure on Post-burn ScarringR01GM112936 · NIGMS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI FINNERTY, CELESTE CAMPBELL · 2015 to 2019
$1.8M
HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) AR072061HHS | NIH | National Institute of General Medical Sciences (NIGMS) GM112936HHS | NIH | National Institute on Aging (U.S. National Institute on Aging) AG000270NIAMS NIH HHS R01 AR072061NIA NIH HHS T32 AG000270NIGMS NIH HHS R01 GM112936
6 · The paper itself

Abstract

Severe burn injury induces a myriad of deleterious effects to skeletal muscle, resulting in impaired function and delayed recovery. Following burn, catabolic signaling and myofiber atrophy are key fiber-intrinsic determinants of weakness; less well understood are alterations in the interstitial environment surrounding myofibers. Muscle quality, specifically alterations in the extracellular matrix (ECM), modulates force transmission and strength. We sought to determine the impact of severe thermal injury on adaptation to the muscle ECM and quantify muscle fibrotic burden. After a 30% total body surface area dorsal burn, spinotrapezius muscle was harvested from mice at 7 (7d,

Indexed as

AnimalsBurnsCell ProliferationCollagenExtracellular MatrixFibroblastsFibrosisGene Expression RegulationHumansMiceMuscle Fibers, SkeletalMuscle, SkeletalMyostatinSignal TransductionTransforming Growth Factor betaCollagenMstn protein, mouseMyostatinTransforming Growth Factor betaburnextracellular matrixfibrogenic/adipogenicmuscle fibrosismyostatinprogenitor cell

Identifiers

PMID32432932
PMCPMC7500217
OpenAlexW3027246558

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.