ArticleChemical research in toxicology2020
Free Radical Production and Characterization of Heat-Not-Burn Cigarettes in Comparison to Conventional and Electronic Cigarettes.
Article in Chemical research in toxicology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed.
- Comparative Indoor Pollution from Glo, Iqos, and Juul, Using Traditional Combustion Cigarettes as Benchmark: Evidence from the Randomized SUR-VAPES AIR Trial.International journal of environmental research and public health · 2020Trial
- Article
- Nicotine-containing products and the cardiovascular system: mechanisms and global health implications.Nature reviews. Cardiology · 2026Review
- Review
- Heated tobacco product aerosol emission compared to cigarette smoke: A scoping review.Toxicology reports · 2026Review
- Global Heated Tobacco Product User Estimates, 2014-2024: Descriptive Surveillance Study Using Manufacturer Disclosures.JMIR public health and surveillance · 2026Article
- The Influence of the Main Components of Tobacco Smoke, E-Cigarettes, and Air Pollutants on the Development of Glomerulonephritis.Journal of clinical medicine · 2026Review
- Heated tobacco products vs conventional cigarettes: a scoping review of cardiovascular and respiratory clinical outcomes.Internal and emergency medicine · 2026Article
- Do the habits and preferences of heated-tobacco-product users affect the emission characteristics of nicotine, PG, and VG?Current research in toxicology · 2026Article
- Smoking as a persistent global health challenge: perspectives on heated tobacco products.Frontiers in public health · 2026Review
- Heated Tobacco Products: Emerging Health Outcomes and Insights into Oxidative Stress and Pro-Inflammatory-Driving Mechanisms.Antioxidants (Basel, Switzerland) · 2025Review
- Short-Term and Long-Term Effects of Electronic Cigarettes on Mouse Lungs Following Nose-Only Exposures.Chemical research in toxicology · 2025Article
- Changes in Concentration of Selected Biomarkers of Exposure in Users of Classic Cigarettes, E-Cigarettes, and Heated Tobacco Products-A Narrative Review.International journal of molecular sciences · 2025Review
- Biomarkers of Exposure to Nicotine and Selected Toxicants in Individuals Who Use Alternative Tobacco Products Sold in Japan and Canada from 2018 to 2019.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Article
- Determination of reactive oxygen species in mainstream smoke from various heated tobacco products.Environmental health and preventive medicine · 2025Article
- An electron paramagnetic resonance time-course study of oxidative stress in the plasma of electronic cigarette exposed rats.Experimental physiology · 2024Article
- Impact of smoking intensity and device cleaning on IQOS emissions: comparison with an array of cigarettes.Tobacco control · 2024Article
- Toxicological Aspects Associated with Consumption from Electronic Nicotine Delivery System (ENDS): Focus on Heavy Metals Exposure and Cancer Risk.International journal of molecular sciences · 2024Review
- Nicotine Delivery of a Menthol-Flavored Heat-not-Burn Tobacco Product During Directed Use.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2024Article
- The long-term effects of heated tobacco product exposure on the central nervous system in a mouse model of prodromal Alzheimer's disease.Scientific reports · 2024Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
With conventional cigarettes, the burning cone reaches temperatures of >900 °C, resulting in the production of numerous toxicants and significant levels of highly reactive free radicals. In attempts to eliminate combustion while still delivering nicotine and flavorings, a newer alternative tobacco product has emerged known as "heat-not-burn" (HnB). These products heat tobacco to temperatures of 250-350 °C depending on the device allowing for the volatilization of nicotine and flavorants while potentially limiting the production of combustion-related toxicants. To better understand how the designs of these new products compare to conventional cigarettes and different styles of electronic cigarettes (e-cigs), we measured and partially characterized their production of free radicals. Smoke or aerosols were trapped by a spin trap phenyl-
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.