ArticleCancer medicine2020
Stromal score as a prognostic factor in primary gastric cancer and close association with tumor immune microenvironment.
Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31 citing papers in PubMed.
- Molecular Characteristics, Potential Mechanisms, and Prognostic Gene Model of Younger Female Patients With Gastric Cancer.Cancer reports (Hoboken, N.J.) · 2026Article
- Construction of a human epidermal growth factor receptor 2-related gene risk model for predicting breast cancer prognosis.Oncology letters · 2026Article
- The Spatiotemporal Heterogeneity of Tumor-Associated Stromal Cells: Reprogramming Plasticity to Unlock Precision Cancer Immunotherapy.Cancer communications (London, England) · 2026Review
- Article
- A novel super-enhancer-related risk model for predicting prognosis and guiding personalized treatment in hepatocellular carcinoma.BMC cancer · 2024Article
- Immune-Related Long Non-Coding RNA Signature Determines Prognosis and Immunotherapeutic Coherence in Esophageal Cancer.Cancer informatics · 2024Article
- Article
- Stemness-related lncRNAs signature as a biologic prognostic model for head and neck squamous cell carcinoma.Apoptosis : an international journal on programmed cell death · 2023Article
- Leveraging various extracellular matrix levels to assess prognosis and sensitivity to immunotherapy in patients with ovarian cancer.Frontiers in oncology · 2023Article
- Genomic analysis of matrix metalloproteinases affecting the prognosis and immunogenic profile of gastric cancer.Frontiers in genetics · 2023Article
- [CD40LG is a novel immune- and stroma-related prognostic biomarker in the tumor microenvironment of invasive breast cancer].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022Article
- Article
- AFF3 is a novel prognostic biomarker and a potential target for immunotherapy in gastric cancer.Journal of clinical laboratory analysis · 2022Article
- SIRGs score may be a predictor of prognosis and immunotherapy response for esophagogastric junction adenocarcinoma.Frontiers in immunology · 2022Article
- DPP4 Is a Potential Prognostic Marker of Thyroid Carcinoma and a Target for Immunotherapy.International journal of endocrinology · 2022Article
- The DNA damage repair-related geneTranslational lung cancer research · 2021Article
- Identification of potential targets of triptolide in regulating the tumor microenvironment of stomach adenocarcinoma patients using bioinformatics.Bioengineered · 2021Article
- Identification of a novel 10 immune-related genes signature as a prognostic biomarker panel for gastric cancer.Cancer medicine · 2021Article
- Article
- Unsupervised Hierarchical Clustering Identifies Immune Gene Subtypes in Gastric Cancer.Frontiers in pharmacology · 2021Article
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6 authors.
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Abstract
backgroundGastric cancer remains one of the major causes for tumor-related deaths worldwide. Our study aimed to provide an understanding of primary gastric cancer and prompt its clinical diagnosis and treatment.
methodsWe integrated the expression profiles and overall survival information of primary gastric cancer in TCGA and GEO database and estimated the stromal score of each sample by the estimate R package. Stromal score and clinicopathologic characteristics associated with overall survival were analyzed by using Cox regression and the Kaplan-Meier method. Gene set enrichment analysis (GSEA) and KEGG analysis were performed to explore the potential molecular mechanism in TCGA dataset. The relationship between immunotherapy-associated markers or immune cell types and stromal score was explored by using Pearson correlation analysis.
resultsA total of 796 samples were collected for the analysis. Patients with stromal score-high showed poor overall survival (P < .01, HR: 1.407, 95% CI: 1.144-1.731) and identified as an independent prognostic factor. KEGG analysis revealed that stromal score actively involved in diverse tumor-associated pathways. GSEA analysis also revealed stromal score associated with diverse immune-related biological processes. Furthermore, stromal score was related with immunotherapy-associated markers and multiple immune cells.
conclusionOur results showed that stromal score could serve as a potential prognostic biomarker in primary gastric cancer and play an important role in the recognition, surveillance, and prognosis of gastric cancer.
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