Evidence map›Paper›PMID 32432174›Full record

ArticleCirculation reports2019

Intravascular Polarimetry for Tissue Characterization of Coronary Atherosclerosis.

Kenichiro Otsuka, Martin Villiger, Seemantini K Nadkarni, Brett E Bouma

Open access · diamondAbstract read
In one paragraph

Article in Circulation reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Kenichiro OtsukaWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Martin VilligerWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Seemantini K NadkarniWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Brett E BoumaWellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, United States.
Massachusetts General Hospital · USHarvard University · USMassachusetts Institute of Technology · US

Funding

TRD3: Percutaneous and Interstitial ImagingP41EB015903 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI Brett E Bouma · 2012 to 2026
$22.4M
Intracoronary imaging of plaque collagen in patientsR01HL119065 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BOUMA, BRETT E, NADKARNI, SEEMANTINI K · 2014 to 2017
$3.2M
NHLBI NIH HHS R01 HL119065NIBIB NIH HHS P41 EB015903
6 · The paper itself

Abstract

The microscopic tissue structure and organization influence the polarization of light. Intravascular polarimetry leverages this compelling intrinsic contrast mechanism by using polarization-sensitive optical frequency domain imaging to measure the polarization properties of the coronary arterial wall. Tissues rich in collagen and smooth muscle cells appear birefringent, while the presence of lipid causes depolarization, offering quantitative metrics related to the presence of important components of coronary atherosclerosis. Here, we review the basic principle, the interpretation of polarization signatures, and first clinical investigations of intravascular polarimetry and discuss how this extension of contemporary intravascular imaging may advance our knowledge and improve clinical practice in the future.

Indexed as

collagenIntracoronary optical coherence tomographymacrophageplaque compositionpolarized lightsmooth muscle cell

Identifiers

PMID32432174
PMCPMC7236778
OpenAlexW2988220281

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.