Evidence map›Paper›PMID 32432046›Full record

ArticleFrontiers in oncology2020

Effects of BMPER, CXCL10, and HOXA9 on Neovascularization During Early-Growth Stage of Primary High-Grade Glioma and Their Corresponding MRI Biomarkers.

Wei Xue, Junfeng Zhang, Haipeng Tong, Tian Xie, Xiao Chen, Bo Zhou, Pengfei Wu, Peng Zhong, Xuesong Du, Yu Guo and 7 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wei XueDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Junfeng ZhangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Haipeng TongDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Tian XieDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Xiao ChenDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Bo ZhouDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Pengfei WuDepartment of Neurosurgery, Daping Hospital, Army Medical University, Chongqing, China.
Peng ZhongDepartment of Pathology, Daping Hospital, Army Medical University, Chongqing, China.
Xuesong DuDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Yu GuoDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Youyuan YangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Heng LiuDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Jingqin FangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Shunan WangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Hao WuDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Kai XuDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.
Weiguo ZhangDepartment of Radiology, Daping Hospital, Army Medical University, Chongqing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neovascularization is required in high-grade glioma (HGG). The objective of this study was to explore neovascularization-related genes and their corresponding MRI biomarkers during the early-growth stage of HGG. Tumor tissues from 30 HGG patients underwent perfusion MRI scanning prior to surgery were used to establish orthotopic xenograft models, pathologically analyze the tumor vasculature and perform transcriptome sequencing. The cases were divided into two groups based on whether the xenograft was successfully established. Microvascular density and BMPER, CXCL10, and HOXA9 expression of surgical specimens in the xenograft-forming group was significantly elevated and the microvascular diameter was significantly reduced,

Indexed as

BMPERCXCL10high-grade gliomaHOXA9neovascularizationPWI-MRI

Identifiers

PMID32432046
PMCPMC7214627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.