Evidence map›Paper›PMID 32431879›Full record

ArticleRoyal Society open science2020

Controlled release of basic fibroblast growth factor from a peptide biomaterial for bone regeneration.

WeiKang Zhao, Yuling Li, Ao Zhou, Xiaojun Chen, Kai Li, Sinan Chen, Bo Qiao, Dianming Jiang

Open access · goldAbstract read
In one paragraph

Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Research progress of vascularization strategies of tissue-engineered bone.Frontiers in bioengineering and biotechnology · 2023
    Review
  11. Review
  12. Fabrication ofFrontiers in bioengineering and biotechnology · 2022
    Article
  13. Review
  14. Article
  15. Tooth Formation: Are the Hardest Tissues of Human Body Hard to Regenerate?International journal of molecular sciences · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

WeiKang ZhaoDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.ORCID 0000-0002-5594-213X
Yuling LiDepartment of Orthopaedics, Affiliated Hospital of North Sichuan Medical College, No. 63 Wenhua Road, Nanchong City, Sichuan Province 637000, People's Republic of China.
Ao ZhouDepartment of Orthopaedics, Third Affiliated Hospital of Chongqing Medical University, No. 1 Shuanghu Road, Chongqing City, Yubei District 401120, People's Republic of China.
Xiaojun ChenDepartment of Orthopaedics, Hospital (T.C.M) Affiliated to Southwest Medical University, No. 182 Chunhui Road, Luzhou City, Sichuan Province, 646000, People's Republic of China.
Kai LiDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Sinan ChenDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Bo QiaoDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
Dianming JiangDepartment of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Chongqing, Yuzhong District 400016, People's Republic of China.
The Affiliated Yongchuan Hospital of Chongqing Medical University · CNAffiliated Hospital of North Sichuan Medical College · CNChongqing Medical University · CNSouthwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Self-assembled peptide scaffolds based on D-RADA16 are an important matrix for controlled drug release and three-dimensional cell culture. In this work, D-RADA16 peptide hydrogels were coated on artificial bone composed of nano-hydroxyapatite/polyamide 66 (nHA/PA66) to obtain a porous drug-releasing structure for treating bone defects. The developed materials were characterized via transmission electron microscopy and scanning electron microscopy. The proliferation and adhesion of bone mesenchymal stem cells (BMSCs) were examined by confocal laser microscopy and CCK-8 experiments. The osteogenic ability of the porous materials towards bone BMSCs was examined

Indexed as

bFGFbone mesenchymal stem cellsporous nHA/PA66self-assembling peptidesustained release

Identifiers

PMID32431879
PMCPMC7211882
OpenAlexW3014810565

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.