Evidence map›Paper›PMID 32431851›Full record

ArticleHealthcare technology letters2020

Severity detection tool for patients with infectious disease.

Girmaw Abebe Tadesse, Tingting Zhu, Nhan Le Nguyen Thanh, Nguyen Thanh Hung, Ha Thi Hai Duong, Truong Huu Khanh, Pham Van Quang, Duc Duong Tran, Lam Minh Yen, Rogier Van Doorn and 7 more

Open access · goldAbstract read
In one paragraph

Article in Healthcare technology letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Modern Machine-Learning Predictive Models for Diagnosing Infectious Diseases.Computational and mathematical methods in medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 4 countries.

Girmaw Abebe TadesseInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.ORCID 0000-0002-2648-9102
Tingting ZhuInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.ORCID 0000-0002-1552-5630
Nhan Le Nguyen ThanhChildren's Hospital Number 1, Ho Chi Minh City, Vietnam.
Nguyen Thanh HungChildren's Hospital Number 1, Ho Chi Minh City, Vietnam.
Ha Thi Hai DuongHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Truong Huu KhanhChildren's Hospital Number 1, Ho Chi Minh City, Vietnam.
Pham Van QuangChildren's Hospital Number 1, Ho Chi Minh City, Vietnam.
Duc Duong TranHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
Lam Minh YenOxford Clinical Research Unit, Ho Chi Minh City, Vietnam.
Rogier Van DoornOxford University Clinical Research Unit, Hanoi, Vietnam.
Nguyen Van HaoHospital for Tropical Diseases, Ho Chi Minh City, Vietnam.
John PrinceInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.
Hamza JavedInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.
Dani KiyassehInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.
Le Van TanOxford Clinical Research Unit, Ho Chi Minh City, Vietnam.
Louise ThwaitesOxford Clinical Research Unit, Ho Chi Minh City, Vietnam.
David A CliftonInstitute of Biomedical Engineering, University of Oxford, Oxford, UK.
University of Oxford · GBChildren's Hospital 2 · VNHospital for Tropical Diseases · VNAngkor Hospital for Children · KHOxford University Clinical Research Unit · VN

Funding

Wellcome Trust 204904/Z/16/Z
6 · The paper itself

Abstract

Hand foot and mouth disease (HFMD) and tetanus are serious infectious diseases in low- and middle-income countries. Tetanus, in particular, has a high mortality rate and its treatment is resource-demanding. Furthermore, HFMD often affects a large number of infants and young children. As a result, its treatment consumes enormous healthcare resources, especially when outbreaks occur. Autonomic nervous system dysfunction (ANSD) is the main cause of death for both HFMD and tetanus patients. However, early detection of ANSD is a difficult and challenging problem. The authors aim to provide a proof-of-principle to detect the ANSD level automatically by applying machine learning techniques to physiological patient data, such as electrocardiogram waveforms, which can be collected using low-cost wearable sensors. Efficient features are extracted that encode variations in the waveforms in the time and frequency domains. The proposed approach is validated on multiple datasets of HFMD and tetanus patients in Vietnam. Results show that encouraging performance is achieved. Moreover, the proposed features are simple, more generalisable and outperformed the standard heart rate variability analysis. The proposed approach would facilitate both the diagnosis and treatment of infectious diseases in low- and middle-income countries, and thereby improve patient care.

Indexed as

ANSD levelautonomic nervous system dysfunctioncardiologyclassifying ANSD levelsdifficult problemdiseaseselectrocardiogramelectrocardiographyenormous healthcare resourcesfeature extractionfrequency domainshealth careHFMDhigh mortality rateinfectious diseaselearning (artificial intelligence)low-cost wearable sensorsmedical computingmedical signal processingmiddle-income countriesneurophysiologypatient carepatient diagnosispatient treatmentphotoplethysmogram waveformsphysiological patient dataproof-of-principleresource-demandingserious infectious diseasesseverity detection toolstandard heart rate variability analysissupport vector machinesupport vector machinestetanus patientsyoung children

Identifiers

PMID32431851
PMCPMC7199289
OpenAlexW2996312388

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.