Evidence map›Paper›PMID 32431798›Full record

ArticleAvicenna journal of medical biotechnology

Gene Expression and Levels of TGF-B in PBMC Is Associated with Severity of Symptoms in Chronic Heart Failure.

Samaneh Saadati, Vajiheh Eskandari, Farzaneh Rahmani, Mohammad Jafar Mahmoudi, Zahra Rahnemoon, Zahra Rahmati, Fatemeh Gorzin, Mona Hedayat, Ali Akbar Amirzargar, Nima Rezaei

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In one paragraph

Article in Avicenna journal of medical biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Samaneh SaadatiDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Vajiheh EskandariCellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Farzaneh RahmaniResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Jafar MahmoudiDepartment of Cardiology, Amir Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Zahra RahnemoonCardiac Heart Center, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Zahra RahmatiDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Fatemeh GorzinDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Mona HedayatDivision of Immunology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Ali Akbar AmirzargarDepartment of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nima RezaeiResearch Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRResearch Network (United States) · USGuilan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTGF-β1 is known to promote cardiac remodeling and fibrosis during Congestive Heart Failure (CHF). In this study, an attempt was made to investigate expression of Transforming Growth Factor beta1 (TGF-β1) and relative expansion or contraction of regulatory T-cell (Tregs) population in peripheral blood of patients with Chronic Heart Failure (CHF).

methodsReal-time PCR assay was used to investigate expression and post-stimulation levels of TGF-β1 in cell culture supernatant of Peripheral Blood Mononuclear Cells (PBMC) of 42 patients with CHF and 42 controls. Flow cytometry was used to identify relative counts of CD4

resultsPBMCs in patients with CHF expressed higher levels of TGF-β1 compared to controls. Post-stimulation levels of TGF-β1 expression were significantly higher in New York Heart Association (NYHA) functional class IV patients compared to stage I patients. Tregs were significantly expanded in PBMC in CHF, while the CD4

conclusionExpansion of Treg population in CHF provides an extrinsic source for TGF-β1 production to induce reactive fibrosis and cardiac remodeling. Relative decrease in Treg population at advanced stages of CHF is indicative of a loss of regulatory characteristics in these cells and unopposed proinflammatory milieu.

Indexed as

Cell culture techniquesChronic heart failureT-lymphocytesTransforming growth factor beta1

Identifiers

PMID32431798
PMCPMC7229453
OpenAlexW3013543844

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.