Evidence map›Paper›PMID 32431669›Full record

SynthesisFrontiers in endocrinology2020

Does Periodontal Inflammation Affect Type 1 Diabetes in Childhood and Adolescence? A Meta-Analysis.

Biagio Rapone, Massimo Corsalini, Ilaria Converti, Maria Teresa Loverro, Antonio Gnoni, Paolo Trerotoli, Elisabetta Ferrara

Registry-linked trialOpen access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06924372 (Application of Salivary Biomarkers in Risk Assessment for Oral Diseases in Children With Type 1 Diabetes), which is not on this map. Cited by 21 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 4 pooled it
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06924372 active not recruitingnot on this mapstarted 2025, after this paper: background citation

Application of Salivary Biomarkers in Risk Assessment for Oral Diseases in Children With Type 1 Diabetes

TypeobservationalSponsorUniversity of Novi SadRan2025 to 2025Enrolled112ConditionsBiomarkers, Saliva, Type 1 Diabetes (T1D), Dental Care for ChildrenArmsTaking saliva samples of unstimulated saliva will be collected in sterile containers, salivets., Dental status, Periodontal status
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 4 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Dental caries and periodontal status in children and adolescents with type 1 diabetes mellitus: an umbrella review.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Review
  8. Review
  9. Observational
  10. Article
  11. The need for integrated research autopsies in the era of precision oral medicine.Journal of the American Dental Association (1939) · 2023
    Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Type 1 diabetes and periodontal disease: a literature review.Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD · 2022
    Review
  18. Update on the Bidirectional Link Between Diabetes and Periodontitis.Advances in experimental medicine and biology · 2022
    Review
  19. Review
  20. Gingival Crevicular Blood as a Potential Screening Tool: A Cross Sectional Comparative Study.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Biagio RaponeDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari, Bari, Italy.
Massimo CorsaliniInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, Bari, Italy.
Ilaria ConvertiDivision of Plastic and Reconstructive Surgery, Department of Emergency and Organ Transplantation, "Aldo Moro" University of Bari, Bari, Italy.
Maria Teresa LoverroInterdisciplinary Department of Medicine, "Aldo Moro" University of Bari, Bari, Italy.
Antonio GnoniDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari, Bari, Italy.
Paolo TrerotoliMedical Statistic, Department of Biomedical Science and Human Oncology, University of "Aldo Moro" Bari, Bari, Italy.
Elisabetta FerraraComplex Operative Unit of Odontostomatology, Hospital S.S. Annunziata, Chieti, Italy.
University of Bari Aldo Moro · ITOspedale SS. Annunziata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of link between periodontal disease and diabetes has created conditions for analyzing new interdisciplinary approach making toward tackling oral health and systemic issues. As periodontal disease is a readily modifiable risk factor this association has potential clinical implications. The aim of this paper was systematically review the extant literature related to analytics data in order to identify the association between type 1 diabetes (T1DM) in childhood and adolescence with periodontal inflammation. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a database search between 2004 and 2019. A manual search of the literature was conducted as an additional phase of the search process, with the aim of identifying studies that were missed in the primary search. One hundred and thirty-nine records were screened and 10 fulfilled the inclusion criteria. Most studies were of moderate methodological quality. Outcomes included assessments of diabetes and periodontal status. In diabetic populations, compared to healthy subjects, interindividual differences in periodontal status are reflected in higher severity of periodontal inflammation. The most reported barriers to evidence uptake were the intrinsic limits of cross-sectional report data and relevant research, and lack of timely research output. Based on the evidence presented within the literature, the aforementioned biomarkers correlate with poor periodontal status in type 1 diabetic patients. Whilst the corpus of the evidence suggests that there may be an association between periodontal status and type 1 diabetes, study designs and methodological limitations hinder interpretation of the current research.

Indexed as

AdolescentBiomarkersChildDiabetes Mellitus, Type 1HumansInflammationPeriodontal DiseasesPrognosisRisk FactorsBiomarkersadolescentschildrenperiodontal diseaseperiodontitistype 1 diabetes

Identifiers

PMID32431669
PMCPMC7214631
OpenAlexW3023007435

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.