ArticleThe American journal of tropical medicine and hygiene2020
The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018.
Article in The American journal of tropical medicine and hygiene, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Effectiveness of indoor residual spraying on malaria control: a systematic review and meta-analysis.Infectious diseases of poverty · 2022Pooled it
- Inhibitory NK receptor expression associates with altered antimalarial function of γδ T cells.PLoS pathogens · 2026Article
- General knowledge and attitude of healthcare professionals and infrastructural readiness prior to implementation of malaria vaccine in selected hospitals in Tororo district, Uganda: a cross-sectional study.BMC public health · 2025Article
- Article
- Differences in phenotype between long-lived memory B cells against Plasmodium falciparum merozoite antigens and variant surface antigens.PLoS pathogens · 2024Article
- Differences in phenotype between long-lived memory B cells againstbioRxiv : the preprint server for biology · 2024Article
- Estimating the under-five malaria risk in Uganda based on the nearest neighbour matched analysis technique.African health sciences · 2024Article
- Article
- Article
- Plasmodium falciparum infection and disease in infancy associated with increased risk of malaria and anaemia in childhood.Malaria journal · 2023Article
- Impact of population based indoor residual spraying with and without mass drug administration with dihydroartemisinin-piperaquine on malaria prevalence in a high transmission setting: a quasi-experimental controlled before-and-after trial in northeastern Uganda.BMC infectious diseases · 2023Article
- East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda.The American journal of tropical medicine and hygiene · 2022Review
- The influence of the environment and indoor residual spraying on malaria risk in a cohort of children in Uganda.Scientific reports · 2022Article
- Biolarviciding implementation in southern Tanzania: Scalability opportunities and challenges.PloS one · 2022Article
- Impact of Malaria Diagnostic Technologies on the Disease Burden in the Sub-Saharan Africa.Journal of tropical medicine · 2022Review
- House design and risk of malaria, acute respiratory infection and gastrointestinal illness in Uganda: A cohort study.PLOS global public health · 2022Article
- Pediatric Cerebral Malaria.Current tropical medicine reports · 2021Article
- Accounting for regional transmission variability and the impact of malaria control interventions in Ghana: a population level mathematical modelling approach.Malaria journal · 2020Article
- Changing malaria fever test positivity among paediatric admissions to Tororo district hospital, Uganda 2012-2019.Malaria journal · 2020Article
Corrections and comments
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Authors and funding
17 authors at 5 institutions in 3 countries.
Funding
Abstract
There is limited evidence on whether malaria elimination is feasible in high-transmission areas of Africa. Between 2007 and 2018, we measured the impact of malaria control interventions in young children enrolled in three clinical trials and two observational studies in Tororo, Uganda, a historically high-transmission area. Data were pooled from children aged 0.5-2 years. Interventions included individually assigned chemoprevention and repeated rounds of indoor residual spraying (IRS) of insecticide. All children received long-lasting insecticidal nets (LLINs) and treatment for symptomatic malaria with artemisinin-based combination therapy. Malaria incidence was measured using passive surveillance and parasite prevalence by microscopy and molecular methods at regular intervals. Poisson's generalized linear mixed-effects models were used to estimate the impact of various control interventions. In total, 939 children were followed over 1,221.7 person years. In the absence of chemoprevention and IRS (reference group), malaria incidence was 4.94 episodes per person year and parasite prevalence 47.3%. Compared with the reference group, implementation of IRS was associated with a 97.6% decrease (95% CI: 93.3-99.1%,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.