SynthesisPhotodermatology, photoimmunology & photomedicine2020
The expression of opsins in the human skin and its implications for photobiomodulation: A Systematic Review.
Synthesis in Photodermatology, photoimmunology & photomedicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 72 citations in OpenAlex.
- Optotransduction Pathway, Exploring Connections with Inflammation.Biomolecules · 2026Article
- The cutaneous microbiome as a dynamic photoprotective interface against solar radiation.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
- Contrasting biological responses of gingival fibroblasts and keratinocyte to blue and violet light irradiation: implications for photobiomodulation use in the therapeutic management of periodontal disease.Lasers in medical science · 2026Article
- Photobiomodulation as an adjuvant for pain relief and healing pre-orthodontic mandibular third molar surgery: double-blinded randomized clinical trial.The Saudi dental journal · 2026Article
- The role and signal pathways of opsin 3 in the skin: from light perception to pathophysiological mechanisms.Frontiers in medicine · 2026Review
- Oral mucosa cues for regeneration using Photobiomodulation.Lasers in medical science · 2025Article
- Introducing Aurora Kinase A as a Gene Target Against Photoaging: A Network Analysis.Journal of lasers in medical sciences · 2025Article
- Photobiomodulation in fibroblasts: from light to healing through molecular pathways, omics and artificial intelligence.Frontiers in bioengineering and biotechnology · 2025Review
- Review of sensory systems deployed by epidermal keratinocytes.Frontiers in cell and developmental biology · 2025Review
- The power of 810 nm near-infrared photobiomodulation therapy for human asthenozoospermia.Scientific reports · 2024Article
- Blue light inhibits cell viability and proliferation in hair follicle stem cells and dermal papilla cells.Lasers in medical science · 2024Article
- Visible light accelerates skin wound healing and alleviates scar formation in mice by adjusting STAT3 signaling.Communications biology · 2024Article
- Expression of opsin and visual cycle-related enzymes in fetal rat skin keratinocytes and cellular response to blue light.Biochemistry and biophysics reports · 2024Article
- Efficacy of Photobiomodulation Therapy in Older Adults: A Systematic Review.Biomedicines · 2024Review
- Melanocytes in regenerative medicine applications and disease modeling.Journal of translational medicine · 2024Review
- A novel investigational preclinical model to assess fluence rate for dental oral craniofacial tissues.Photodiagnosis and photodynamic therapy · 2024Article
- Article
- All Light, Everywhere? Photoreceptors at Nonconventional Sites.Physiology (Bethesda, Md.) · 2024Review
- Potential application of PBM use in hair follicle organoid culture for the treatment of androgenic alopecia.Materials today. Bio · 2023Review
- Photobiomodulation in dental extraction therapy: Postsurgical pain reduction and wound healing.Journal of the American Dental Association (1939) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundSkin is the organ most extensively exposed to light of a broad range of wavelengths. Several studies have reported that skin expresses photoreceptive molecules called opsins. However, the identity and functional role of opsins in the human skin remain elusive. We aim to summarize current scientific evidence on the types of opsins expressed in the skin and their biological functions.
methodsA primary literature search was conducted using PubMed to identify articles on dermal opsins found in nonhuman animals and humans.
resultsTwenty-two articles, representing, however, a non-exhaustive selection of the scientific papers published in this specific field, met the inclusion criteria. In nonhuman animals, opsins and opsin-like structures have been detected in the skin of fruit fly, zebrafish, frog, octopus, sea urchin, hogfish, and mouse, and they mediate skin color change, light avoidance, shadow reflex, and circadian photoentrainment. In humans, opsins are present in various skin cell types, including keratinocytes, melanocytes, dermal fibroblasts, and hair follicle cells. They have been shown to mediate wound healing, melanogenesis, hair growth, and skin photoaging.
conclusionDermal opsins have been identified across many nonhuman animals and humans. Current evidence suggests that opsins have biological significance beyond light reception. In nonhuman animals, opsins are involved in behaviors that are critical for survival. In humans, opsins are involved in various functions of the skin although the underlying molecular mechanisms remain unclear. Future investigation on elucidating the mechanism of dermal opsins will be crucial to expand the therapeutic benefits of photobiomodulation for various skin disorders.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.