ArticleJournal of assisted reproduction and genetics2020
Oocyte retrieval outcomes among adolescent transgender males.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Ovarian stimulation and oocyte cryopreservation in females and transgender males aged 18 years or less: a systematic review.Frontiers in endocrinology · 2023Pooled it
- Clinical and ethical perspectives of ovarian stimulation and oocyte cryopreservation in adolescents: 6 years experience from a tertiary centre.Human reproduction open · 2025Article
- REPRODUCTIVE HEALTH IN TRANS AND GENDER-DIVERSE PATIENTS: Gonadal tissue cryopreservation in transgender and gender-diverse people.Reproduction (Cambridge, England) · 2024Review
- Reproductive Health in Trans and Gender Diverse Patients: Effects of transmasculine gender-affirming hormone therapy on future reproductive capacity: clinical data, animal models, and gaps in knowledge.Reproduction (Cambridge, England) · 2024Review
- Safety and effectiveness of controlled ovarian stimulation and oocyte retrieval during prepubertal and peripubertal period.Journal of assisted reproduction and genetics · 2024Article
- Family Building in Transgender Patients: Modern Strategies with Assisted Reproductive Technology Treatment.Transgender health · 2024Article
- Clinical management of transgender and non-binary patients in the fertility preservation service: Current evidence.International journal of transgender health · 2024Review
- Fertility treatment outcomes in transgender men with a history of testosterone therapy.F&S reports · 2023Article
- In vitro fertilization outcomes in a mouse model of gender-affirming hormone therapy in transmasculine youth.F&S science · 2023Article
- Update on bioethical, medical and fertility issues in gender incongruence during transition age.Journal of endocrinological investigation · 2023Review
- "Lights and Shades" of Fertility Preservation in Transgender Men Patients: A Clinical and Pathological Review.Life (Basel, Switzerland) · 2023Review
- Fertility, Contraception, and Fertility Preservation in Trans Individuals.Deutsches Arzteblatt international · 2023Review
- Fertility counseling guide for transgender and gender diverse people.International journal of transgender health · 2023Article
- Fertility preservation in pediatric healthcare: a review.Frontiers in endocrinology · 2023Review
- Fertility preservation in transgender men and the need for uniform, comprehensive counseling.F&S reports · 2022Article
- Comparison between slow freezing and vitrification of ovarian tissue cryopreservation in assigned female at birth transgender people receiving testosterone therapy: data on histological and viability parameters.Journal of assisted reproduction and genetics · 2022Article
- Fertility Preservation for Adolescent and Young Adult Transmen: A Case Series and Insights on Oocyte Cryopreservation.Frontiers in endocrinology · 2022Article
- Ovarian stimulation outcomes among transgender men compared with fertile cisgender women.Journal of assisted reproduction and genetics · 2020Article
- Barriers to fertility preservation access in transgender and gender diverse adolescents: a narrative review.Therapeutic advances in reproductive healthReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare fertility preservation (FP) outcomes among adolescent transgender males with those of cisgender females.
methodsThis retrospective cohort study included nine adolescent transgender males and 39 adolescent cisgender females who underwent FP between January 2017-April 2019 and September 2013-April 2019, respectively. The transgender males were referred before initiating testosterone, and the cisgender females were referred due to cancer diagnosis before starting anticancer treatment. Statistical analyses compared assisted reproductive technology (ART) data and FP outcomes between two groups.
resultsBasal FSH levels (5.4 ± 1.7 mIU/mL) and AFC (19.8 ± 5.6) of all transgender males were normal compared with standard references. The mean age of transgender males and cisgender females was similar (16.4 ± 1.1 vs 15.5 ± 1.3 years, respectively, P = 0.064). The amount of FSH used for stimulation was significantly lower among the former compared with the latter (2416 ± 1041 IU vs 4372 ± 1877 IU, P < 0.001), but the duration of stimulation was similar (12.6 ± 4.0 and 10.1 ± 2.8 days, P = 0.086). Peak estradiol level was significantly higher among transgender males compared with cisgender females (3073 ± 2637 pg/mL vs 1269 ± 975 pg/mL, respectively, P = 0.018), but there were no significant differences in number of retrieved oocytes between the two groups (30.6 ± 12.8 vs 22 ± 13.2, P = 0.091), number of MII oocytes (25.6 ± 12.9 vs 18.8 ± 11.2, P = 0.134), or maturity rates (81.5 ± 10.0% vs 85.4 ± 14.6%, P = 0.261).
conclusionsAdolescent transgender males have an excellent response to ovulation stimulation before initiating testosterone treatment. Oocyte cryopreservation is, therefore, a feasible and effective way for them to preserve their fertility for future biological parenting.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.