Evidence map›Paper›PMID 32430709›Full record

Trial reportReproductive sciences (Thousand Oaks, Calif.)2020

Acute Glucose Load, Inflammation, Oxidative Stress, Nonenzymatic Glycation, and Screening for Gestational Diabetes.

Megan L Jones, Irina A Buhimschi, Guomao Zhao, Anna Bartholomew, Jordan Smith-Timms, Kara M Rood, Catalin S Buhimschi

Registry-linked trialAbstract readClinical Trial
PubMed Publisher
In one paragraph

Trial report in Reproductive sciences (Thousand Oaks, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03029546 (The Effect of Acute Glucose Loading on Level of Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes During Pregnancy), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03029546 completednot on this map

The Effect of Acute Glucose Loading on Level of Expression of Advanced Glycation End Products in Women Screened for Gestational Diabetes During Pregnancy

TypeobservationalSponsorOhio State UniversityRan2015 to 2019Enrolled105ConditionsInflammation
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Gestational Oxidative Stress and OGTT: Are Pregnant Women's Fears Justified?Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Megan L JonesDepartment of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA. mjobgyn@gmail.com.
Irina A BuhimschiCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Guomao ZhaoCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH, USA.
Anna BartholomewDepartment of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.
Jordan Smith-TimmsDepartment of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.
Kara M RoodDepartment of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.
Catalin S BuhimschiDepartment of Obstetrics & Gynecology, The Ohio State University College of Medicine, Columbus, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate if oral glucose tolerance test (OGTT) associates with changes in maternal symptoms (ie, flushing, sweating), blood nonenzymatic advanced glycation end products (AGE), acute-phase reactive inflammatory markers, and oxidative stress.

methodsProspective case-control study of patients screened for gestational diabetes mellitus (GDM). One hundred nonfasting, second-trimester consecutive pregnant women allocated to either 50 g OGTT or water. Five women who had a 3-hour fasting 100 g OGTT also enrolled. Maternal serum glucose, AGE, soluble receptor for AGE (sRAGE), interleukin (IL)-6, and C-reactive protein (CRP) were immunoassayed. Total radical-trapping antioxidant parameter (TRAP) estimated with antioxidant capacityperoxyl assay. Data corrected for gestational age and maternal body mass index.

resultsDuring 50 g OGTT there was a decrease in systolic blood pressure not accompanied by the onset of adverse clinical symptoms. There was a decrease in serum glucose levels 1 hour after water (P = .019) but not glucose ingestion. Serum CRP (P = .001) but not IL-6 was increased. The AGE, sRAGE, and TRAP levels remained unchanged. Similar results were seen during 100 g OGTT, except serum glucose was significantly elevated after 1 hour.

conclusionResults suggest screening tools for gestational diabetes are safe and clinically well tolerated during pregnancy. CLINICAL

trial registrationClinicalTrials.gov NCT03029546.

Indexed as

AdultCase-Control StudiesDiabetes, GestationalFemaleGlucoseGlycation End Products, AdvancedHumansInflammationMass ScreeningOxidative StressPregnancyYoung AdultGlucoseGlycation End Products, Advancedadvanced glycation end productsdiabetesglucosepregnancyRAGE

Identifiers

PMID32430709

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.