Evidence map›Paper›PMID 32430707›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2020

Gestational and Hormonal Effects on Magnesium Sulfate's Ability to Inhibit Mouse Uterine Contractility.

Blessing E Osaghae, Sarah Arrowsmith, Susan Wray

Abstract read
PubMed Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Blessing E OsaghaeDepartment of Molecular and Cellular Physiology, University Department, Harris-Wellbeing Preterm Birth Research Centre, Institute of Translational Medicine, University of Liverpool, First floor Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK.
Sarah ArrowsmithDepartment of Molecular and Cellular Physiology, University Department, Harris-Wellbeing Preterm Birth Research Centre, Institute of Translational Medicine, University of Liverpool, First floor Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK.
Susan WrayDepartment of Molecular and Cellular Physiology, University Department, Harris-Wellbeing Preterm Birth Research Centre, Institute of Translational Medicine, University of Liverpool, First floor Liverpool Women's Hospital, Crown Street, Liverpool, L8 7SS, UK. s.wray@liv.ac.uk.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnesium sulfate is used as a tocolytic, but clinical efficacy has been seriously questioned. Our objective was to use controlled ex vivo conditions and known pregnancy stages, to investigate how 2 key factors, hormones and gestation, affect magnesium's tocolytic ability. We hypothesized that these factors could underlie the varying clinical findings around magnesium's efficacy. Myometrial strips were obtained from nonpregnant (n = 10), mid-pregnant (n = 12), and term-pregnant (n = 11) mouse uterus. The strips were mounted in organ baths superfused with oxygenated physiological saline at pH 7.4 and 37 °C. The effect of different concentrations of MgSO

Indexed as

AnimalsDose-Response Relationship, DrugFemaleGonadal Steroid HormonesMagnesium SulfateMiceMyometriumOrgan Culture TechniquesOxytocinPregnancyUterine ContractionGonadal Steroid HormonesMagnesium SulfateOxytocincontractionoxytocinpreterm birthtocolysisuterus

Identifiers

PMID32430707

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.