Evidence map›Paper›PMID 32430632›Full record

ArticleEJNMMI radiopharmacy and chemistry2020

Synthesis, in vitro and in vivo evaluation of

Vidya Narayanaswami, Junchao Tong, Ferdinando Fiorino, Beatrice Severino, Rosa Sparaco, Elisa Magli, Flavia Giordano, Peter M Bloomfield, Jaya Prabhakaran, J John Mann and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EJNMMI radiopharmacy and chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 7 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 3 countries.

Vidya NarayanaswamiAzrieli Centre for Neuro-Radiochemistry, Research Imaging Centre & Preclinical Imaging, Centre for Addiction and Mental Health, Toronto, Ontario, M5T-1R8, Canada.
Junchao TongAzrieli Centre for Neuro-Radiochemistry, Research Imaging Centre & Preclinical Imaging, Centre for Addiction and Mental Health, Toronto, Ontario, M5T-1R8, Canada.
Ferdinando FiorinoDepartment of Pharmacy, University of Naples, Via D. Montesano, 49, 8013, Naples, Italy.
Beatrice SeverinoDepartment of Pharmacy, University of Naples, Via D. Montesano, 49, 8013, Naples, Italy.
Rosa SparacoDepartment of Pharmacy, University of Naples, Via D. Montesano, 49, 8013, Naples, Italy.
Elisa MagliDepartment of Pharmacy, University of Naples, Via D. Montesano, 49, 8013, Naples, Italy.
Flavia GiordanoDepartment of Pharmacy, University of Naples, Via D. Montesano, 49, 8013, Naples, Italy.
Peter M BloomfieldAzrieli Centre for Neuro-Radiochemistry, Research Imaging Centre & Preclinical Imaging, Centre for Addiction and Mental Health, Toronto, Ontario, M5T-1R8, Canada.
Jaya PrabhakaranMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
J John MannMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA.
Neil VasdevAzrieli Centre for Neuro-Radiochemistry, Research Imaging Centre & Preclinical Imaging, Centre for Addiction and Mental Health, Toronto, Ontario, M5T-1R8, Canada.
Kenneth DahlAzrieli Centre for Neuro-Radiochemistry, Research Imaging Centre & Preclinical Imaging, Centre for Addiction and Mental Health, Toronto, Ontario, M5T-1R8, Canada. KennethF.Dahl@gmail.com.ORCID http://orcid.org/0000-0003-2948-2042
J S Dileep KumarMolecular Imaging and Neuropathology Division, New York State Psychiatric Institute, New York, USA. Dileep.Kumar@nyspi.columbia.edu.
Centre for Addiction and Mental Health · CAUniversity of Naples Federico II · ITNew York Psychoanalytic Society and Institute · USColumbia University Irving Medical Center · US

Funding

Neuro-PET Radiotracer Discovery for Imaging Glycogen Synthase Kinase-3R01AG054473 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI VASDEV, NEIL · 2017 to 2020
$1.7M
NIH HHS R01AG054473
6 · The paper itself

Abstract

backgroundSerotonin 1A (5-HT

resultsSyntheses of 1-3 and corresponding precursors for radiolabeling were achieved from isonicotinic, picolinic acid or picolino nitrile. In vitro binding studies demonstrated nanomolar affinity of the compounds for 5-HT

conclusionDespite efficient radiolabeling, results from PET imaging experiments limit the application of [

Indexed as

5-HT1A receptorCarbon-11PETSerotoninα1-adrenergic receptor

Identifiers

PMID32430632
PMCPMC7237647
OpenAlexW3026416224

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.