Evidence map›Paper›PMID 32430600›Full record

ReviewCurrent cardiology reports2020

Advances in PET-Based Cardiac Amyloid Radiotracers.

Cesia Gallegos, Edward J Miller

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05374564 (Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05374564 phase1completednot on this mapstarted 2022, after this paper: background citation

Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy

TypeinterventionalSponsorYale UniversityRan2022 to 2024Enrolled12ConditionsCardiomyopathies, PrimaryArms(18F)Flutemetamol
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Multifaceted roles of neutrophils in cardiac disease.Journal of leukocyte biology · 2025
    Review
  4. Cardiac amyloidosis: Innovations in diagnosis and treatment.European heart journal supplements : journal of the European Society of Cardiology · 2025
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Cardiac hybrid imaging: novel tracers for novel targets.Journal of geriatric cardiology : JGC · 2021
    Article
  10. Review
  11. Multimodality Imaging in Cardiac Amyloidosis.Current cardiology reports · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Cesia GallegosSection of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208017, New Haven, CT, 06520-8017, USA.
Edward J MillerSection of Cardiovascular Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208017, New Haven, CT, 06520-8017, USA. edward.miller@yale.edu.ORCID 0000-0002-2156-5962
Yale University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gold standard for diagnosis of cardiac amyloidosis (CA) is endomyocardial biopsy showing Congo red staining followed by mass spectroscopy, but the diagnosis can also be made with high certainty by demonstration of typical cardiac imaging features along with amyloid on biopsy of another involved organ. The use of cardiac imaging techniques to detect amyloid deposits may frequently obviate the need for invasive methods in order to ascertain the presence, and potentially the type, of amyloid deposition. PURPOSE OF REVIEW: We aim to review the evidence behind the development of novel positron emission tomography (PET) radiotracers for demonstrating cardiac amyloid deposition and potentially distinguishing between light-chain (AL) or transthyretin (ATTR) cardiac amyloidosis. RECENT

findingsMultiple recent studies have shown that thioflavin-analogue tracers such as

Indexed as

AmyloidAmyloidosisCardiologyHeartHeart DiseasesHumansPositron-Emission TomographyPrealbuminRadionuclide ImagingAmyloidPrealbuminAmyloidBone scintigraphyPositron emission tomographyRadiotracersTransthyretin

Identifiers

PMID32430600
OpenAlexW3027829704

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.