Evidence map›Paper›PMID 32430580›Full record

ReviewEuropean journal of nuclear medicine and molecular imaging2021

Kinetic modeling and parametric imaging with dynamic PET for oncological applications: general considerations, current clinical applications, and future perspectives.

Antonia Dimitrakopoulou-Strauss, Leyun Pan, Christos Sachpekidis

Abstract readReview
In one paragraph

Review in European journal of nuclear medicine and molecular imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers.

0numbers the graph read from it
0cells of the map it votes in
119citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

119 citing papers in PubMed.

  1. A pilot study of [European journal of nuclear medicine and molecular imaging · 2025
    Trial
  2. Article
  3. Article
  4. Article
  5. Patlak-Guided Self-Supervised Learning for Dynamic PET Denoising.IEEE transactions on radiation and plasma medical sciences · 2026
    Article
  6. Review
  7. Article
  8. Review
  9. A microscopic computational simulation of [Physics in medicine and biology · 2026
    Article
  10. Review
  11. Article
  12. Exploring extended [European journal of nuclear medicine and molecular imaging · 2026
    Article
  13. Article
  14. Review
  15. Mitigating bladder signal inEJNMMI physics · 2026
    Article
  16. Article
  17. Comparison of multi-organ CT image segmentation tools for whole-body [European journal of nuclear medicine and molecular imaging · 2026
    Article
  18. Article
  19. Review
  20. Article

59 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Antonia Dimitrakopoulou-StraussClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany. a.dimitrakopoulou-strauss@dkfz.de.ORCID 0000-0003-0338-9472
Leyun PanClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.
Christos SachpekidisClinical Cooperation Unit Nuclear Medicine, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dynamic PET (dPET) studies have been used until now primarily within research purposes. Although it is generally accepted that the information provided by dPET is superior to that of conventional static PET acquisitions acquired usually 60 min post injection of the radiotracer, the duration of dynamic protocols, the limited axial field of view (FOV) of current generation clinical PET systems covering a relatively small axial extent of the human body for a dynamic measurement, and the complexity of data evaluation have hampered its implementation into clinical routine. However, the development of new-generation PET/CT scanners with an extended FOV as well as of more sophisticated evaluation software packages that offer better segmentation algorithms, automatic retrieval of the arterial input function, and automatic calculation of parametric imaging, in combination with dedicated shorter dynamic protocols, will facilitate the wider use of dPET. This is expected to aid in oncological diagnostics and therapy assessment. The aim of this review is to present some general considerations about dPET analysis in oncology by means of kinetic modeling, based on compartmental and noncompartmental approaches, and parametric imaging. Moreover, the current clinical applications and future perspectives of the modality are outlined.

Indexed as

Positron-Emission TomographyPositron Emission Tomography Computed TomographyAlgorithmsHumansKineticsTomography, X-Ray ComputedDynamic PETFeature extractionKinetic modelingOncologyParametric imaging

Identifiers

PMID32430580
PMCPMC7835173

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.