ArticleEuropean journal of nutrition2021
Effects of diet, habitual water intake and increased hydration on body fluid volumes and urinary analysis of renal fluid retention in healthy volunteers.
Article in European journal of nutrition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Kinetics of 5% and 20% albumin: A controlled crossover trial in volunteers.Acta anaesthesiologica Scandinavica · 2022Trial
- Urinary creatinine in very low gestational age neonates: importance for interpretation of creatinine-normalized urinary amino acids.Jornal de pediatria · 2026Article
- Article
- Constant plasma volume and colloid osmotic pressure after infusion of albumin 20%: A secondary analysis.Physiological reports · 2025Article
- Volume Kinetics of Gelofusine 4% During Vascular Surgery.Clinical pharmacokinetics · 2025Observational
- Plasma and serum volume remain unchanged following a 12-h fast from food and drink despite changes in blood and urinary hydration markers.European journal of clinical nutrition · 2025Article
- Effects of concentrated urine on complications and plasma creatinine: a prospective study in elective non-cardiac surgery patients.Frontiers in medicine · 2025Article
- Diuretic responses to Ringer's solution and 20% albumin at different arterial pressures.Physiological reports · 2024Article
- Detection of low urine output by measuring urinary biomarkers.BMC nutrition · 2024Article
- Water Consumption: Effect on Energy Expenditure and Body Weight Management.Current obesity reports · 2023Review
- Quantifying the daily intake of water from morning and spot urine samples; retrospective analysis of a clinical trial in volunteers.BMC nutrition · 2023Article
- Concentrated urine, low urine flow, and postoperative elevation of plasma creatinine: A retrospective analysis of pooled data.PloS one · 2023Article
- Renal Water Conservation and Plasma Creatinine in Colorectal Cancer Surgery: A Single-Group Clinical Study.Frontiers in medicine · 2022Article
- Serum Creatinine Levels and Nephrocheck® Values With and Without Correction for Urine Dilution-A Multicenter Observational Study.Frontiers in medicine · 2022Article
- Renal water conservation and the volume kinetics of fluid-induced diuresis: A retrospective analysis of two cohorts of elderly men.Clinical and experimental pharmacology & physiology · 2021Article
- Preoperative Concentrated Urine Increases the Incidence of Plasma Creatinine Elevation After Major Surgery.Frontiers in medicine · 2021Article
- Chronic Dehydration in Nursing Home Residents.Nutrients · 2020Article
- The kinetics of isotonic and hypertonic resuscitation fluids is dependent on the sizes of the body fluid volumes.Journal of anaesthesiology, clinical pharmacologyArticle
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo increase our knowledge about the causes and physiological consequences of concentrated urine, the relevance of which in the general population is uncertain.
methodsTwenty healthy volunteers (mean age 42 years) recorded all intake of food and water for 2 weeks. During the 2nd week, they increased their daily consumption of water by 716 mL (32%). The volunteers delivered a 24-h and a morning urine sample for analysis of osmolality and creatinine during the first 4 days of both weeks, and a sample each time they voided on the other days. The water content of food and liquid was calculated and the body fluid volumes were measured by bioimpedance. Haemodynamic stability was assessed with the passive leg-raising test.
resultsThere was a curvilinear correlation between the daily intake of water and biomarkers measured in the 24-h collection of urine (coefficient of determination 0.37-0.70). Habitual low intake of water was associated with larger body fluid volumes. The increased fluid intake during the 2nd week was best reflected in the 24-h collection (-15 and -20% for the osmolality and creatinine, respectively, P < 0.002), while morning urine and body fluid volumes were unchanged. Increased fluid intake improved the haemodynamic stability in volunteers with a low intake of water (< median), but only in those who had minimally concentrated morning urine.
conclusionsThe 24-h collection reflected recent intake of fluid, whereas the morning urine seemed to mirror long-term corrections of the fluid balance. Concentrated urine was associated with larger body fluid volumes.
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