Evidence map›Paper›PMID 32430521›Full record

ArticleSurgical endoscopy2021

Comparison of lymph node evaluation and yield among patients undergoing open and minimally invasive surgery for gallbladder adenocarcinoma.

Ahmad Hamad, Jordan M Cloyd, Mary Dillhoff, Andrei Manilchuk, Timothy M Pawlik, Allan Tsung, Aslam Ejaz

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Ahmad HamadDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Jordan M CloydDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Mary DillhoffDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Andrei ManilchukDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Timothy M PawlikDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Allan TsungDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA.
Aslam EjazDepartment of Surgery, Division of Surgical Oncology, Wexner Medical Center and James Cancer Hospital and Solove Research Institute, The Ohio State University, 320 W. 10th Ave., M-260 Starling-Loving Hall, Columbus, OH, USA. aslam.ejaz@osumc.edu.
The Ohio State University · USThe Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAssessment of regional lymph nodes (LN) is essential for determining prognosis among patients with gallbladder cancer (GBC). The impact of surgical technique on LN yield has not been well explored. We investigated the impact of minimally invasive surgery (MIS; robotic or laparoscopic) on the evaluation and retrieval of regional LN for patients with GBC.

methodsWe queried the National Cancer Database (NCDB) to identify patients with GBC who underwent curative-intent surgery between 2010 and 2015. Patients with metastatic disease or those with missing data on surgical resection or LN evaluation were excluded.

resultsWe identified 2014 patients who underwent an open (n = 1141, 56.6%) or MIS approach (n = 873, 43.4%) for GBC and met the inclusion criteria. Patients who underwent MIS were older (open: 68 years, IQR: 60, 75 vs. MIS: 70 years, IQR (61, 77); P = 0.02), and were more commonly treated at a comprehensive community cancer program (P < 0.001). Approximately 3 out of 4 patients (n = 1468, 72.9%) underwent an evaluation of regional LN, with nearly half of these patients (n = 607, 41.7%) having LN metastasis. Among patients who underwent a regional lymphadenectomy, average lymph node yield was 3 (IQR: 1, 6) and was similar between the two groups (P = 0.04). After controlling for all factors, operative approach was not associated with likelihood of receiving a lymphadenectomy during curative-intent resection (OR 0.81, 95% CI 0.63-1.04; P = 0.11).

conclusionIn conclusion, patients undergoing curative-intent resection for GBC had similar rates of lymph node evaluation and yield regardless of operative approach. Over one-quarter of patients did not undergo a lymphadenectomy at the time of surgery. Further studies are needed to identify barriers to lymph node evaluation and yield among patients undergoing surgery for gallbladder cancer. Presented at the 2019 2nd World Congress of the International Laparoscopic Liver Society, Tokyo, Japan.

Indexed as

AdenocarcinomaAgedFemaleGallbladder NeoplasmsHumansLaparoscopyLymphatic MetastasisLymph Node ExcisionLymph NodesMaleMiddle AgedMinimally Invasive Surgical ProceduresRetrospective StudiesGallbladder cancerLymph nodeMinimally invasive surgery

Identifiers

PMID32430521
OpenAlexW3026039161

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.