ArticleJournal of clinical pathology2021
Fibronodular hepatocellular carcinoma-a new variant of liver cancer: clinical, pathological and radiological correlation.
Article in Journal of clinical pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- HCC: role of pre- and post-treatment tumor biology in driving adverse outcomes and rare responses to therapy.Abdominal radiology (New York) · 2021Review
- Hepatocellular carcinoma: making sense of morphological heterogeneity, growth patterns, and subtypes.Human pathology · 2021Review
- Pathologic and molecular features of hepatocellular carcinoma: An update.World journal of hepatology · 2021Review
- Scirrhous Hepatocellular Carcinoma: Systematic Review and Pooled Data Analysis of Clinical, Radiological, and Histopathological Features.Journal of hepatocellular carcinoma · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
aimsTo establish and define a new, not previously reported hepatocellular carcinoma (HCC) variant, termed fibronodular HCC (FN-HCC).
methodsWe retrospectively reviewed 290 HCC cases and identified 29 FN-HCC and 24 scirrhous HCC (SCHCC). Clinical, pathological and radiological features of FN-HCC were reviewed and compared with 30 conventional HCCs (CV-HCC) and SC-HCC.
resultsFN-HCCs were more likely to arise in non-advanced fibrotic livers with lower advanced Barcelona Clinic Liver Cancer (BCLC) stage, had lower rates of progression and longer time to progression and were more likely to be surgically resected compared with CV-HCCs and SC-HCCs. Imaging analysis of FN-HCCs demonstrated higher rates of non-peripheral washout and a new distinct pattern of enhancement which is characterised by the presence of multiple rounded nodules within a lesion embedded in fibrotic-appearing parenchyma.
conclusionsFN-HCC may represent a specific variant of HCC with distinct pathological, radiological and clinical features with potential ramifications for outcome.
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