ArticlemBio2020
Coevolution of Eukaryote-like Vps4 and ESCRT-III Subunits in the Asgard Archaea.
Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Large eukaryotic DNA viruses encode ESCRT machinery for membrane remodelling.Nature microbiology · 2026Article
- The archaeal roots of eukaryotic life.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Molecular structure of the ESCRT-III-based archaeal CdvAB cell division machinery.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Distinct filament morphology and membrane tethering features of the dual FtsZ paralogs in Odinarchaeota.The EMBO journal · 2025Article
- Phylogenomic Analyses Reveal that Panguiarchaeum Is a Clade of Genome-Reduced Asgard Archaea Within the Njordarchaeia.Molecular biology and evolution · 2025Article
- The evolution and mechanism of bacterial and archaeal ESCRT-III-like systems.Current opinion in structural biology · 2025Review
- Revealing the diversity of bacterial and archaeal organelles via comparative genomics.Molecular biology of the cell · 2025Review
- Asgard Arf GTPases can act as membrane-associating molecular switches with the potential to function in organelle biogenesis.Nature communications · 2025Article
- Article
- The Asgard archaeal origins of Arf family GTPases involved in eukaryotic organelle dynamics.Nature microbiology · 2025Article
- The Asgard archaeal ESCRT-III system forms helical filaments and remodels eukaryotic-like membranes.The EMBO journal · 2025Article
- Article
- Diversity, Origin and Evolution of the ESCRT Systems.bioRxiv : the preprint server for biology · 2024Article
- Roles of ESCRT-III polymers in cell division across the tree of life.Current opinion in cell biology · 2023Review
- The multifaceted interactions between pathogens and host ESCRT machinery.PLoS pathogens · 2023Review
- The expanding Asgard archaea invoke novel insights into Tree of Life and eukaryogenesis.mLife · 2022Article
- Asgard archaea shed light on the evolutionary origins of the eukaryotic ubiquitin-ESCRT machinery.Nature communications · 2022Article
- The unstable evolutionary position ofmLife · 2022Article
- Tracing back variations in archaeal ESCRT-based cell division to protein domain architectures.PloS one · 2022Article
- Progress and Challenges in Archaeal Molecular Biology.Methods in molecular biology (Clifton, N.J.) · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The emergence of the endomembrane system is a key step in the evolution of cellular complexity during eukaryogenesis. The endosomal sorting complex required for transport (ESCRT) machinery is essential and required for the endomembrane system functions in eukaryotic cells. Recently, genes encoding eukaryote-like ESCRT protein components have been identified in the genomes of Asgard archaea, a newly proposed archaeal superphylum that is thought to include the closest extant prokaryotic relatives of eukaryotes. However, structural and functional features of Asgard ESCRT remain uncharacterized. Here, we show that Vps4, Vps2/24/46, and Vps20/32/60, the core functional components of the Asgard ESCRT, coevolved eukaryote-like structural and functional features. Phylogenetic analysis shows that Asgard Vps4, Vps2/24/46, and Vps20/32/60 are closely related to their eukaryotic counterparts. Molecular dynamics simulation and biochemical assays indicate that Asgard Vps4 contains a eukaryote-like microtubule-interacting and transport (MIT) domain that binds the distinct type 1 MIT-interacting motif and type 2 MIT-interacting motif in Vps2/24/46 and Vps20/32/60, respectively. The Asgard Vps4 partly, but much more efficiently than homologs from other archaea, complements the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.