Evidence map›Paper›PMID 32430450›Full record

ArticleBMJ open2020

Cannabidiol (CBD) and Δ

Anastasia Suraev, Ronald R Grunstein, Nathaniel S Marshall, Angela L D'Rozario, Christopher J Gordon, Delwyn J Bartlett, Keith Wong, Brendon J Yee, Ryan Vandrey, Chris Irwin and 3 more

Open access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Multinational Association of Supportive Care in Cancer (MASCC) guidelines: cannabis for psychological symptoms including insomnia, anxiety, and depression.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
    Pooled it
  2. Pooled it
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  6. Cannabidiol for moderate-severe insomnia: a randomized controlled pilot trial of 150 mg of nightly dosing.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024
    Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
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  15. Article
  16. Article
  17. The Different Faces of Insomnia.Frontiers in psychiatry · 2021
    Article
  18. Effects of Cannabinoids on Sleep and their Therapeutic Potential for Sleep Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Review
  19. Prescribing medicinal cannabis.Australian prescriber · 2020
    Review
  20. Cannabinoids, Endocannabinoids and Sleep.Frontiers in molecular neuroscience · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Anastasia SuraevWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.ORCID 0000-0002-5993-2246
Ronald R GrunsteinWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Nathaniel S MarshallWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Angela L D'RozarioWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Christopher J GordonWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Delwyn J BartlettWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Keith WongWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Brendon J YeeWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia.
Ryan VandreyBehavioral Pharmacology Research Unit, Johns Hopkins University, Baltimore, Maryland, USA.
Chris IrwinMenzies Health Institute Queensland, School Allied Health Sciences, Griffith University, Gold Coast, Queensland, Australia.
Jonathon C ArnoldThe University of Sydney, Lambert Initiative for Cannabinoid Therapeutics, Sydney, New South Wales, Australia.
Iain S McGregorThe University of Sydney, Lambert Initiative for Cannabinoid Therapeutics, Sydney, New South Wales, Australia.
Camilla M HoyosWoolcock Institute of Medical Research, Centre for Sleep and Chronobiology, Sydney, New South Wales, Australia camilla.hoyos@sydney.edu.au.
The University of Sydney · AURoyal Prince Alfred Hospital · AUGriffith University · AUJohns Hopkins University · USWoolcock Institute of Medical Research · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInsomnia is a highly prevalent and costly condition that is associated with increased health risks and healthcare utilisation. Anecdotally, cannabis use is frequently reported by consumers to promote sleep. However, there is limited research on the effects of cannabis on sleep and daytime function in people with insomnia disorder using objective measures. This proof-of-concept study will evaluate the effects of a single dose of an oral cannabis-based medicine on sleep and daytime function in participants with chronic insomnia disorder. METHODS AND ANALYSIS: A randomised, crossover, placebo-controlled, single-dose study design will be used to test the safety and efficacy of an oral oil solution ('ETC120') containing 10 mg Δ ETHICS AND DISSEMINATION: Ethics approval was received from Bellberry Human Research Ethics Committee (2018-04-284). The findings will be disseminated in a peer-reviewed open-access journal and at academic conferences. TRIAL REGISTRATION NUMBER: ANZCTRN12619000714189.

Indexed as

CannabidiolCannabisSleep Initiation and Maintenance DisordersAdultDouble-Blind MethodDronabinolHumansMiddle AgedRandomized Controlled Trials as TopicCannabidiolDronabinolcannabinoidshigh-density EEGinsomniaprotocol

Identifiers

PMID32430450
PMCPMC7239553
OpenAlexW3027745507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.