Evidence map›Paper›PMID 32430393›Full record

ArticleDisease models & mechanisms2020

Zebrafish models of skeletal dysplasia induced by cholesterol biosynthesis deficiency.

Rebecca A Anderson, Kevin T Schwalbach, Stephanie R Mui, Elizabeth E LeClair, Jolanta M Topczewska, Jacek Topczewski

Open access · goldAbstract read
In one paragraph

Article in Disease models & mechanisms, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Rebecca A AndersonDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.ORCID 0000-0001-9065-235X
Kevin T SchwalbachDevelopmental Biology Program, Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.ORCID 0000-0001-9136-0586
Stephanie R MuiDevelopmental Biology Program, Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.
Elizabeth E LeClairDepartment of Biological Sciences, DePaul University, Chicago, IL 60614, USA.ORCID 0000-0002-4935-4577
Jolanta M TopczewskaDevelopmental Biology Program, Stanley Manne Children's Research Institute, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, IL 60611, USA.ORCID 0000-0003-1876-5039
Jacek TopczewskiDepartment of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA j-topczewski@northwestern.edu.ORCID 0000-0001-6023-9556
Lurie Children's Hospital · USNorthwestern University · USDePaul University · US

Funding

Identification of gene involved in late stage zebrafish craniofacial developmentF31DE023481 · NIDCR · LURIE CHILDREN'S HOSPITAL OF CHICAGO · PI ANDERSON, REBECCA ANN · 2013 to 2015
$108k
NIDCR NIH HHS F31 DE023481
6 · The paper itself

Abstract

Human disorders of the post-squalene cholesterol biosynthesis pathway frequently result in skeletal abnormalities, yet our understanding of the mechanisms involved is limited. In a forward-genetic approach, we have found that a late-onset skeletal mutant, named

Indexed as

AnimalsAnimals, Genetically ModifiedBone and BonesBone Diseases, DevelopmentalCholesterolChondrocytesCollagen Type XDisease Models, AnimalGenetic Predisposition to DiseaseIntramolecular TransferasesLiverMixed Function OxygenasesMutationPhenotypeZebrafishZebrafish ProteinsCholesterolCollagen Type XIntramolecular Transferaseslanosterol synthasemethylsterol monooxygenaseMixed Function OxygenasesZebrafish ProteinsCholesterolChondrodysplasia punctataLssMsmo1Skeletal dysplasiaZebrafish

Identifiers

PMID32430393
PMCPMC7328163
OpenAlexW3028561232

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.