ArticleProceedings of the National Academy of Sciences of the United States of America2020
Cognitive and brain development is independently influenced by socioeconomic status and polygenic scores for educational attainment.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49citing papers in PubMed
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49 citing papers in PubMed, 108 citations in OpenAlex.
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- Evaluating Transferability of ComBat Harmonization of Diffusion Tensor Magnetic Resonance Imaging Data.Annals of biomedical engineering · 2026Article
- Family income and polygenic scores are independently but not interactively associated with cognitive performance among youth genetically similar to European reference populations.Development and psychopathology · 2025Article
- Polygenic architecture of brain structure and function, behaviors, and psychopathologies in children.Nature communications · 2025Article
- Polygenic Scores of Executive Function Provide Limited Support for Genetic Confounding With Socio-Economic Measures.Genes, brain, and behavior · 2025Article
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- Can socioeconomic status moderate the effect of a conflictive family environment on brain structure and externalizing/internalizing behavior in children and adolescents?Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2025Article
- Racial and ethnic socioenvironmental inequity and neuroimaging in psychiatry: a brief review of the past and recommendations for the future.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Long-term impact of digital media on brain development in children.Scientific reports · 2024Article
- Utilizing maternal prenatal cognition as a predictor of newborn brain measures of intellectual development.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2024Article
- Triple Interactions Between the Environment, Brain, and Behavior in Children: An ABCD Study.Biological psychiatry · 2024Article
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Authors and funding
36 authors at 19 institutions in 9 countries.
Nicholas JuddDepartment of Neuroscience, Karolinska Institute, Stockholm, 17165, Sweden.
Bruno SauceDepartment of Neuroscience, Karolinska Institute, Stockholm, 17165, Sweden.ORCID 0000-0002-9544-0150
John WiedenhoeftDepartment of Medical Statistics, University of Göttingen, Göttingen, 37073, Germany.ORCID 0000-0002-6935-1517
Jeshua TrompDepartment of Cognitive Psychology, Leiden University, Leiden, 2311, The Netherlands.
Bader ChaaraniDepartment of Psychiatry, University of Vermont, Burlington, VT 05405.ORCID 0000-0002-3932-6273
Alexander SchliepDepartment of Computer Science and Engineering, University of Gothenburg, Gothenburg, 41756, Sweden.
Betteke van NoortHochschule für Gesundheit und Medizin, Medical School Berlin, Berlin, 14197, Germany.ORCID 0000-0002-9768-3383
Jani PenttiläDepartment of Social and Health Care, Psychosocial Services Adolescent Outpatient Clinic, University of Tampere, Lahti, 33100, Finland.
Yvonne GrimmerDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.
Corinna InsenseeDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, 37075, Germany.
Andreas BeckerDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, 37075, Germany.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.ORCID 0000-0003-4595-1144
Arun L W BokdeDiscipline of Psychiatry, School of Medicine, Trinity College Dublin, Dublin, D02 PN40, Ireland.
Erin Burke QuinlanSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom.
Sylvane DesrivièresCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.
Antoine GrigisNeuroSpin, French Alternative Energies and Atomic Energy Commission (CEA), Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.
Penny GowlandSir Peter Mansfield Imaging Centre, School of Physics and Astronomy, University of Nottingham, Nottingham, NG7 2RD, United Kingdom.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, 10117, Germany.
Bernd IttermannPhysikalisch-Technische Bundesanstalt, Berlin, 38116, Germany.
Jean-Luc MartinotINSERM Unit 1000 "Neuroimaging & Psychiatry," Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, 75006, France.
Marie-Laure Paillère MartinotINSERM Unit 1000 "Neuroimaging & Psychiatry," Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, 75006, France.
Eric ArtigesINSERM Unit 1000 "Neuroimaging & Psychiatry," Institut National de la Santé et de la Recherche Médicale, University Paris Saclay, University Paris Descartes, Paris, 75006, France.
Frauke NeesDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.
Dimitri Papadopoulos OrfanosNeuroSpin, French Alternative Energies and Atomic Energy Commission (CEA), Université Paris-Saclay, F-91191 Gif-sur-Yvette, France.ORCID 0000-0002-1242-8990
Tomáš PausBloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, University of Toronto, Toronto, ON M6A 2E1, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry and Psychotherapy, University Medical Center, Göttingen, 37075, Germany.
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.
Sabina MillenetDepartment of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, 69117, Germany.
Juliane H FröhnerDepartment of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, 01087, Germany.
Michael N SmolkaDepartment of Psychiatry, Technische Universität Dresden, Dresden, 01062, Germany.ORCID 0000-0001-5398-5569
Henrik WalterDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité, Universitätsmedizin Berlin, Berlin, 10117, Germany.ORCID 0000-0002-9403-6121
Robert WhelanSchool of Psychology, Trinity College Dublin, Dublin, D02 PN40, Ireland.ORCID 0000-0002-2790-7281
Gunter SchumannCentre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, SE5 8AF, United Kingdom.
Hugh GaravanDepartment of Psychiatry, University of Vermont, Burlington, VT 05405.
Torkel KlingbergDepartment of Neuroscience, Karolinska Institute, Stockholm, 17165, Sweden; torkel.klingberg@ki.se.
Heidelberg University · DEInserm · FRKarolinska Institutet · SEKing's College London · GBUniversitätsmedizin Göttingen · DECharité - Universitätsmedizin Berlin · DECommissariat à l'Énergie Atomique et aux Énergies Alternatives · FRTechnische Universität Dresden · DETrinity College Dublin · IEUniversity of Mannheim · DEUniversity of Vermont · USLeiden University · NLMSB Medical School Berlin · DEPhysikalisch-Technische Bundesanstalt · DETampere University · FIUniversity of Gothenburg · SEUniversity of Göttingen · DEUniversity of Nottingham · GBUniversity of Toronto · CA
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MAxon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5MMeaningful Data Compression and Reduction of High-Throughput Sequencing DataU01CA198952 · NCI · RUTGERS, THE STATE UNIV OF N.J. · PI FARACH-COLTON, MARTIN · 2015 to 2017
$981kENIGMA World Aging CenterR56AG058854 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2018 to 2018
$683kDepartment of HealthMedical Research Council MR/N000390/1Medical Research Council MR/N027558/1Medical Research Council MR/R00465X/1Medical Research Council MR/S020306/1MRF_ MRF-058-0004-RG-DESRIMRF_ MRF-058-0009-RG-DESR-C0759NCI NIH HHS U01 CA198952NIA NIH HHS R56 AG058854NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772
Abstract
Genetic factors and socioeconomic status (SES) inequalities play a large role in educational attainment, and both have been associated with variations in brain structure and cognition. However, genetics and SES are correlated, and no prior study has assessed their neural associations independently. Here we used a polygenic score for educational attainment (EduYears-PGS), as well as SES, in a longitudinal study of 551 adolescents to tease apart genetic and environmental associations with brain development and cognition. Subjects received a structural MRI scan at ages 14 and 19. At both time points, they performed three working memory (WM) tasks. SES and EduYears-PGS were correlated (
Indexed as
CognitionEducational StatusAcademic SuccessAdolescentAdultBrainFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMemory, Short-TermMultifactorial InheritanceSocial ClassYoung Adultdevelopmentpolygenic scoressocioeconomic statusstructural MRIworking memory
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