Evidence map›Paper›PMID 32430296›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Enhancing Gamma Oscillations Restores Primary Motor Cortex Plasticity in Parkinson's Disease.

Andrea Guerra, Francesco Asci, Valentina D'Onofrio, Valerio Sveva, Matteo Bologna, Giovanni Fabbrini, Alfredo Berardelli, Antonio Suppa

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 2 syntheses or guidelines pooled it, 104 citations in OpenAlex.

  1. Pooled it
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  6. Macroscale Gradient-Informed Neural Oscillation Topography in Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026
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  16. [Research progress on combined transcranial electromagnetic stimulation in clinical application in brain diseases].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Andrea GuerraIRCCS Neuromed, Pozzilli (IS) 86077, Italy.ORCID 0000-0001-6601-4964
Francesco AsciDepartment of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.ORCID 0000-0003-0717-3521
Valentina D'OnofrioDepartment of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
Valerio SvevaDepartment of Human Neurosciences, Sapienza University of Rome, Rome 00185, Italy.
Matteo BolognaIRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Giovanni FabbriniIRCCS Neuromed, Pozzilli (IS) 86077, Italy.
Alfredo BerardelliIRCCS Neuromed, Pozzilli (IS) 86077, Italy alfredo.berardelli@uniroma1.it.ORCID 0000-0003-3598-3142
Antonio SuppaIRCCS Neuromed, Pozzilli (IS) 86077, Italy.ORCID 0000-0001-9903-5550
Istituto Neurologico Mediterraneo · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In humans, γ oscillations in cortical motor areas reflect asynchronous synaptic activity and contribute to plasticity processes. In Parkinson's disease (PD), γ oscillatory activity in the basal ganglia-thalamo-cortical network is altered and the LTP-like plasticity elicited by intermittent theta burst stimulation (iTBS) is reduced in the primary motor cortex (M1). In this study, we tested whether transcranial alternating current stimulation (tACS) delivered at γ frequency promotes iTBS-induced LTP-like plasticity in M1 in PD patients. Sixteen patients (OFF condition) and 16 healthy subjects (HSs) underwent iTBS during γ-tACS (iTBS-γ tACS) and during sham-tACS (iTBS-sham tACS) in two sessions. Motor-evoked potentials (MEPs) evoked by single-pulse transcranial magnetic stimulation and short-interval intracortical inhibition (SICI) were recorded before and after the costimulation. A subgroup of patients also underwent iTBS during β tACS. iTBS-sham tACS facilitated single-pulse MEPs in HSs, but not in patients. iTBS-γ tACS induced a larger MEP facilitation than iTBS-sham tACS in both groups, with similar values in patients and HSs. In patients, SICI improved after iTBS-γ tACS. The effect produced by iTBS-γ tACS on single-pulse MEPs correlated with disease duration, while changes in SICI correlated with Unified Parkinson's Disease Rating Scale Part III scores. The effect of iTBS-β tACS on both single-pulse MEPs and SICI was similar to that obtained in the iTBS-sham tACS session. Our data suggest that γ oscillations have a role in the pathophysiology of the abnormal LTP-like plasticity in PD. Entraining M1 neurons at the γ rhythm through tACS may be an effective method to restore impaired plasticity.

Indexed as

Transcranial Direct Current StimulationAgedAged, 80 and overEvoked Potentials, MotorFemaleGamma RhythmHumansMaleMiddle AgedMotor CortexNeuronal PlasticityParkinson Diseasegammamotor cortexParkinson's diseaseplasticitytACSTMS

Identifiers

PMID32430296
PMCPMC7294804
OpenAlexW3026974845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.