ArticleScience signaling2020
A protein kinase A-regulated network encodes short- and long-lived cellular memories.
Article in Science signaling, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Biomolecular Condensates in Combined and Recurrent Plant Stresses: Integrating Phase Separation, Signal Prioritization, and Cross-Stress Memory.International journal of molecular sciences · 2026Review
- Modulation of the stress-activated protein kinases Hog1/p38 and a TORC1-dependent kinase by curcumin is stress granule-dependent.The Journal of biological chemistry · 2026Article
- Computational Systems Biology Approaches to Cellular Aging - Integrating Network Maps and Dynamical Models.Quantitative biology (Beijing, China) · 2025Article
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- Stress resilience in plants: the complex interplay between heat stress memory and resetting.The New phytologist · 2025Review
- Enhanced cellular longevity arising from environmental fluctuations.Cell systems · 2024Article
- Optimal phenotypic adaptation in fluctuating environments.Biophysical journal · 2023Article
- The regulatory mechanism of the yeast osmoresponse under different glucose concentrations.iScience · 2023Article
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- Do microbes have a memory? History-dependent behavior in the adaptation to variable environments.Frontiers in microbiology · 2022Review
- Memorizing environmental signals through feedback and feedforward loops.Current opinion in cell biology · 2021Review
- Age-dependent decline in stress response capacity revealed by proteins dynamics analysis.Scientific reports · 2020Article
- Learning Without Neurons: A Review of Associative Memory in Protists.The Journal of eukaryotic microbiologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cells can store memories of prior experiences to modulate their responses to subsequent stresses, as seen for the protein kinase A (PKA)-mediated general stress response in yeast, which is required for resistance against future stressful conditions. Using microfluidics and time-lapse microscopy, we quantitatively analyzed how the cellular memory of stress adaptation is encoded in single yeast cells. We found that cellular memory was biphasic. Short-lived memory was mediated by trehalose synthase and trehalose metabolism. Long-lived memory was mediated by PKA-regulated stress-responsive transcription factors and cytoplasmic messenger ribonucleoprotein granules. Short- and long-lived memory could be selectively induced by different priming input dynamics. Computational modeling revealed how the PKA-mediated regulatory network could encode previous stimuli into memories with distinct dynamics. This biphasic memory-encoding scheme might represent a general strategy to prepare for future challenges in rapidly changing environments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.