Evidence map›Paper›PMID 32430087›Full record

ArticleJournal of the International Neuropsychological Society : JINS2020

Frontal Behavior Syndromes in Idiopathic Normal Pressure Hydrocephalus as a Function of Alzheimer's Disease Biomarker Status.

Madison Niermeyer, Chad Gaudet, Paul Malloy, Irene Piryatinsky, Stephen Salloway, Petra Klinge, Athene Lee

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Madison NiermeyerDivision of Physical Medicine & Rehabilitation, University of Utah, Salt Lake City, UT.
Chad GaudetDepartment of Psychology, University of Rhode Island, Kingston, RI.
Paul MalloyDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI.
Irene PiryatinskyDepartment of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA.
Stephen SallowayDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI.
Petra KlingeDepartment of Neurosurgery, Warren Alpert Medical School, Brown University, Providence, RI.
Athene LeeDepartment of Psychiatry and Human Behavior, Warren Alpert Medical School, Brown University, Providence, RI.ORCID 0000-0002-8828-8701
Providence College · USBeth Israel Deaconess Medical Center · USUniversity of Rhode Island · USUniversity of Utah · US

Funding

Tracking and Evaluation CoreU54GM115677 · NIGMS · BROWN UNIVERSITY · PI ROUNDS, SHARON IRENE SMITH · 2016 to 2025
$45.0M
NIGMS NIH HHS U54 GM115677
6 · The paper itself

Abstract

objectivesCognitive impairment and apathy are well-documented features of idiopathic normal pressure hydrocephalus (iNPH). However, research examining other neuropsychiatric manifestations of iNPH is scant, and it is unknown whether the neuropsychiatric presentation differs for iNPH patients with comorbid Alzheimer's disease (AD) versus iNPH without AD. This study aims to advance our understanding of neuropsychiatric syndromes associated with iNPH.

methodsFifty patients from Butler Hospital's Normal Pressure Hydrocephalus Clinic met inclusion criteria. Caregiver ratings on the Frontal Systems Behavior Scale (FrSBe) were examined to appraise changes in apathy, executive dysfunction, and disinhibition. Patients also completed cognitive tests of global cognition, psychomotor speed, and executive functioning. AD biomarker status was determined by either amyloid-beta (Aβ) positron emission tomography (PET) imaging or cerebrospinal fluid (CSF) total tau to Aβ-42 ratio.

resultsResults revealed clinically significant elevations on the FrSBe's apathy and executive dysfunction scales and modest correlations among these scales and cognitive measures. Of the 44 patients with available neuroimaging or CSF draw data, 14 presented with comorbid AD. Relative to the iNPH-only group, the iNPH + AD group showed a larger increase from pre-illness to current informant ratings on the executive dysfunction scale, but not the apathy or disinhibition scales.

conclusionsThese results replicate and extend prior research by identifying apathy and executive dysfunction as prominent neuropsychiatric symptoms of iNPH and suggest comorbid AD exacerbates dysexecutive behaviors. Future research is warranted to examine the effects of comorbid AD pathology in response to shunt surgery for iNPH, neuropsychiatric symptom changes, and resultant caregiver burden.

Indexed as

AgedAlzheimer DiseaseAmyloid beta-PeptidesApathyBiomarkersCaregiversExecutive FunctionFemaleHumansHydrocephalus, Normal PressureMaleMiddle AgedNeuropsychological TestsPeptide FragmentsPositron-Emission Tomographytau ProteinsAmyloid beta-PeptidesBiomarkersPeptide Fragmentstau ProteinsAmyloidApathyCerebrospinal fluidCognitionDementiaExecutive functionHydrocephalus

Identifiers

PMID32430087
PMCPMC7554119
OpenAlexW3026205491

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.