Evidence map›Paper›PMID 32430024›Full record

ArticleJournal of experimental & clinical cancer research : CR2020

ABCA8 is regulated by miR-374b-5p and inhibits proliferation and metastasis of hepatocellular carcinoma through the ERK/ZEB1 pathway.

Yifeng Cui, Shuhang Liang, Shugeng Zhang, Congyi Zhang, Yunzheng Zhao, Dehai Wu, Jiabei Wang, Ruipeng Song, Jizhou Wang, Dalong Yin and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of experimental & clinical cancer research : CR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 52 citations in OpenAlex.

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  8. MiRNAs: main players of cancer drug resistance target ABC transporters.Naunyn-Schmiedeberg's archives of pharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 1 country.

Yifeng CuiDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Shuhang LiangDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Shugeng ZhangDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Congyi ZhangDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yunzheng ZhaoDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Dehai WuDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jiabei WangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Ruipeng SongDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Jizhou WangDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Dalong YinDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Yao LiuDepartment of Hepatobiliary Surgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui, China.
Shangha PanKey Laboratory of Hepatosplenic Surgery, Ministry of Education, Harbin, Heilongjiang, China.
Xirui LiuDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Yan WangDepartment of Colorectal Surgery, Harbin Medical University Cancer Hospital, Harbin, Heilongjiang, China.
Jihua HanDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Fanzheng MengDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Bo ZhangDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Hongrui GuoDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Zhaoyang LuDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. lzy76772005@163.com.
Lianxin LiuDepartment of Hepatic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. LiuLX@ems.hrbmu.edu.cn.
First Affiliated Hospital of Harbin Medical University · CNHarbin Medical University · CNUniversity of Science and Technology of China · CNThird Affiliated Hospital of Harbin Medical University · CN

Funding

Changjiang Scholars and Innovative Research Team in University IRT1122Heilongjiang Provincial Postdoctoral Science Foundation LBH-Z18132Heilongjiang Provincial Postdoctoral Science Foundation LBH-Z19182National Natural Scientific Foundation of China 81301807National Natural Scientific Foundation of China 81602058National Natural Scientific Foundation of China 81772588National Natural Scientific Foundation of China 81773194National Natural Scientific Foundation of China 81902954National Natural Scientific Foundation of China 81972230
6 · The paper itself

Abstract

backgroundATP binding cassette subfamily A member 8 (ABCA8) belongs to the ATP binding cassette (ABC) transporter superfamily. ABCA8 is a transmembrane transporter responsible for the transport of organics, such as cholesterol, and drug efflux. Some members of the ABC subfamily, such as ABCA1, may inhibit cancer development. However, the mechanism of ABCA8 in the process of cancer activation is still ambiguous.

methodsThe expression of ABCA8 in human hepatocellular carcinoma (HCC) tissues and cell lines was examined using qPCR, immunoblotting, and immunohistochemical staining. The effects of ABCA8 on the proliferation and metastasis of HCC were examined using in vitro and in vivo functional tests. A luciferase reporter assay was performed to explore the binding between microRNA-374b-5p (miR-374b-5p) and the ABCA8 3'-untranslated region (UTR).

resultsABCA8 was frequently down-regulated in HCC and this down-regulation was negatively correlated with prognosis. The overexpression of ABCA8 inhibited growth and metastasis in HCC, whereas the knockdown of ABCA8 exerted the antithetical effects both in vivo and in vitro. ABCA8 was down-regulated by miR-374b-5p; this down-regulation can induce epithelial transformation to mesenchyme via the ERK/ZEB1 signaling pathway and promote HCC progression.

conclusionWe exposed the prognostic value of ABCA8 in HCC, and illuminated a novel pathway in ABCA8-regulated inhibition of HCC tumorigenesis and metastasis. These findings may lead to a new targeted therapy for HCC through the regulation of ABCA8, and miR-374b-5p.

Indexed as

MAP Kinase Signaling SystemAnimalsATP-Binding Cassette TransportersCarcinoma, HepatocellularCell Line, TumorCell ProliferationHeterograftsHumansLiver NeoplasmsMaleMice, Inbred BALB CMice, NudeMicroRNAsMiddle AgedNeoplasm MetastasisTransfectionABCA8 protein, humanATP-Binding Cassette TransportersMicroRNAsMIRN374 microRNA 374, humanZEB1 protein, humanZinc Finger E-box-Binding Homeobox 1ATP binding cassette subfamily a member 8Epithelial to mesenchymal transitionHepatocellular carcinomaTherapeutic target

Identifiers

PMID32430024
PMCPMC7236190
OpenAlexW3028275018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.