Trial reportJournal of neuroengineering and rehabilitation2020
Selective neural electrical stimulation restores hand and forearm movements in individuals with complete tetraplegia.
Trial report in Journal of neuroengineering and rehabilitation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 10 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Neural Functional Electrical Stimulation for the Recovery of Grasping Movements for Patient With Quadriplegia.
Evaluation of Non-invasive Control Interfaces for Operating Assistive Devices for Tetraplegic Individuals
Relevance of Virtual Reality Assessment of Control Interfaces for a Neuroprosthesis That Stimulates the Upper Limbs of Quadriplegic Individuals
Who cites it
10 citing papers in PubMed, 34 citations in OpenAlex.
- A methodological framework for the efficient characterization of peripheral nerve stimulation parameters.Journal of neural engineering · 2025Trial
- Restoring hand grasping for patients with a complete tetraplegia with selective epineural stimulation: a parsimonious thus relevant clinical approach.Journal of neuroengineering and rehabilitation · 2026Article
- Methodological optimization for eliciting robust median nerve somatosensory evoked potentials for realtime single trial applications.Journal of neural engineering · 2026Article
- Epineural stimulation on distal brachial plexus for functional restoration of the upper limb in a primate study.Frontiers in neurology · 2025Article
- Electrical stimulation in upper limb assistance: opportunities and challenges.Frontiers in neuroscience · 2025Review
- Electrical Stimulation and Motor Function Rehabilitation in Spinal Cord Injury: A Systematic Review.Cureus · 2024Review
- Biomimetic Peripheral Nerve Stimulation Promotes the Rat Hindlimb Motion Modulation in Stepping: An Experimental Analysis.Cyborg and bionic systems (Washington, D.C.) · 2024Article
- Electrical stimulation therapy for peripheral nerve injury.Frontiers in neurology · 2023Review
- Activating effective functional hand movements in individuals with complete tetraplegia through neural stimulation.Scientific reports · 2022Article
- New Stimulation Device to Drive Multiple Transverse Intrafascicular Electrodes and Achieve Highly Selective and Rich Neural Responses.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe hypothesized that a selective neural electrical stimulation of radial and median nerves enables the activation of functional movements in the paralyzed hand of individuals with tetraplegia. Compared to previous approaches for which up to 12 muscles were targeted through individual muscular stimulations, we focused on minimizing the number of implanted electrodes however providing almost all the needed and useful hand movements for subjects with complete tetraplegia.
methodsWe performed acute experiments during scheduled surgeries of the upper limb with eligible subjects. We scanned a set of multicontact neural stimulation cuff electrode configurations, pre-computed through modeling simulations. We reported the obtained isolated and functional movements that were considered useful for the subject (different grasping movements).
resultsIn eight subjects, we demonstrated that selective stimulation based on multicontact cuff electrodes and optimized current spreading over the active contacts provided isolated, compound, functional and strong movements; most importantly 3 out of 4 had isolated fingers or thumb flexion, one patient performed a Key Grip, another one the Power and Hook Grips, and the 2 last all the 3 Grips. Several configurations were needed to target different areas within the nerve to obtain all the envisioned movements. We further confirmed that the upper limb nerves have muscle specific fascicles, which makes it possible to activate isolated movements.
conclusionsThe future goal is to provide patients with functional restoration of object grasping and releasing with a minimally invasive solution: only two cuff electrodes above the elbow. Ethics Committee / ANSM clearance prior to the beginning of the study (inclusion period 2016-2018): CPP Sud Méditerranée, #ID-RCB:2014-A01752-45, first acceptance 10th of February 2015, amended 12th of January 2016.
trial registration(www.clinicaltrials.gov): #NCT03721861, Retrospectively registered on 26th of October 2018.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.