Evidence map›Paper›PMID 32429931›Full record

SynthesisBMC cancer2020

Prognostic and diagnostic value of circRNA expression in colorectal carcinoma: a meta-analysis.

Jinpeng Yuan, Dongming Guo, Xinxin Li, Juntian Chen

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. The Emerging Role of Circular RNAs in Prostate Cancer: A Systematic Review.Frontiers in cell and developmental biology · 2021
    Pooled it
  5. Article
  6. Review
  7. Tailored Systemic Therapy for Colorectal Cancer Liver Metastases.International journal of molecular sciences · 2021
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Jinpeng YuanDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Dongming GuoDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China.
Xinxin LiDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China. savageli23@163.com.
Juntian ChenDepartment of Gastrointestinal Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou, China. 13809846668@163.com.ORCID http://orcid.org/0000-0002-3197-9421
Shantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCircular RNAs (circRNAs) are research hotspots in the network of noncoding RNAs in numerous tumours. The purpose of our study was to evaluate the clinicopathological, prognostic and diagnostic value of circRNAs in colorectal cancer.

methodsThe PubMed, Cochrane Library, and Web of Science online databases were searched for relevant studies before May 15, 2019. Pooled hazard ratios (HRs) and odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the association between circRNAs expression, and overall survival (OS) and clinical parameters. Pooled sensitivity, specificity, and the area under the curve (AUC) were employed to assess the diagnostic value of circRNAs.

resultsA total of 19 studies were enrolled in this meta-analysis, with 11 on clinicopathological parameters, 8 on prognosis and 7 on diagnosis. For clinicopathological and prognostic value, elevated expression of oncogenic circRNAs was correlated with poor clinical parameters (tumor size: OR = 1.769, 95% CI: 1.097-2.852; differentiation grade: OR = 1.743, 95% CI: 1.032-2.946; TNM stage: OR = 3.320, 95% CI: 1.529-7.207; T classification: OR = 3.410, 95% CI: 2.088-5.567; lymph node metastasis: OR = 3.357, 95% CI: 2.160-5.215; distal metastasis: OR = 4.338, 95% CI: 2.503-7.520) and worse prognosis (HR = 2.29, 95% CI: 1.50-3.52). However, elevated expression of tumor-suppressor circRNAs was correlated with better clinical parameters (differentiation grade: OR = 0.453, 95% CI: 0.261-0.787; T classification: OR = 0.553, 95% CI: 0.328-0.934; distal metastasis: OR = 0.196, 95% CI: 0.077-0.498) and favorable prognosis (HR = 0.37, 95% CI: 0.22-0.64). For diagnostic value, the pooled sensitivity, specificity, and AUC were 0.82 (95% CI, 0.75-0.88), 0.72 (95% CI, 0.66-0.78), and 0.82 (95% CI, 0.78-0.85), respectively.

conclusionsThese results indicate that circRNAs may be potential biomarkers for the diagnosis and prognosis of colorectal cancer.

Indexed as

Biomarkers, TumorColorectal NeoplasmsHumansPrognosisRNA, CircularBiomarkers, TumorRNA, CircularCircular RNAColorectal cancerDiagnosisPrognosis

Identifiers

PMID32429931
PMCPMC7238613
OpenAlexW3027600805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.