ArticleBMC cancer2020
Multiple HPV 16 infection with two strains: a possible marker of neoplastic progression.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 57 citations in OpenAlex.
- Determination of Human Papillomavirus prevalence in the female population from Zanjan, Iran.Preventive medicine reports · 2026Article
- HPV genotype-specific p16/Ki67 expression with machine learning-assisted assessment in cervical neoplasia.Frontiers in oncology · 2026Article
- Prevalence and genotypic characterization of human papillomavirus in Iraqi women: a retrospective study of 2,193 cases.Virology journal · 2025Article
- Clinical study on the pathogenic risks of different genotypes of high-risk HPV infection and multiple infections.Infectious agents and cancer · 2025Article
- Multiple high-risk human papillomavirus infections exacerbate cervical lesion risk: epidemiological evidence from suining, Sichuan.Virology journal · 2025Article
- Evaluating the Predictive Performance of miR-124-2 and FAM19A4 for Cervical Lesions in a Single Center from Romania: A Prospective Study.Journal of clinical medicine · 2025Article
- Risk stratification and conservative management of women aged 25-40 years with cervical intraepithelial neoplasia grade 2(CIN2).BMC infectious diseases · 2025Observational
- Prevalence and Genotype Distribution of High-Risk HPV Genotypes Among Women in Greece: A Retrospective Analysis of 3500 Women.Cancers · 2025Article
- A 10-year Retrospective Analysis on HPV Genotype Switching in a Tertiary Center in China: Infection Characterization and Clinical Outcome.Journal of medical virology · 2025Article
- Differential Mediating Roles of Immune-Inflammatory Cells in ≥HSIL Women: A Focus on HPV and CD4/CD8 or NLR.Journal of inflammation research · 2025Article
- Prevalence of human papillomavirus and cervical lesions among elderly women: an unignored challenge to cervical cancer prevention.Annals of medicine · 2024Article
- Prevalence of Carcinogenic Genotypes of HPV-Infected Women in a Ten-Year Period (2014-2023) in Vojvodina, Serbia.Medicina (Kaunas, Lithuania) · 2024Article
- Epidemiology of human papillomavirus infection in women from Xiamen, China, 2013 to 2023.Frontiers in public health · 2024Article
- Outcomes and associated factors of cervical human papillomavirus infection among 608 women in Shenzhen, China, 2018-2023.Frontiers in public health · 2024Article
- Prevalence characteristics of cervical human papillomavirus infection in Chengdu and Aba District, Sichuan Province, China.PloS one · 2024Article
- Prevalence and genotype distribution of HPV6/11/16/18 infections among 180,276 outpatient females from a Women's and Children's Central Hospital, 2015-2021, Chengdu, China.Scientific reports · 2023Article
- Article
- Chemical Peeling Therapy Using Phenol for the Cervico-Vaginal Intraepithelial Neoplasia.Viruses · 2023Article
- Prevalence of human papillomavirus in eyelid carcinoma among Koreans: a clinicopathological study.BMC ophthalmology · 2023Article
- Clinical and epidemiological features of high-risk human papillomavirus infection in patients with cervical intraepithelial lesions.BMC women's health · 2023Article
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4 authors at 1 institution in 1 country.
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Abstract
backgroundWe studied the cases of single and multiple HPV infection and analyzed the correlation with negative cases, and preneoplastic and neoplastic lesions of the uterine cervix with the aim of making a contribution to the prognostic factor under discussion.
methodsNine hundred nine women undergoing second level screening because they had been positive at cervical cytology were enrolled. All the patients underwent colposcopy and cervical biopsy with viral genotyping. We divided mHPV infection based on the number of genotypes present: infections with 2 strains, 3 strains, 4 strains and 5 or more strains. STATISTICAL ANALYSIS: The analysis of the data was made using the χ2 test. Contingency tables were created to evaluate the correlation between single, multiple and CIN2+ infections. Values with p < 0.05 were considered statistically significant.
resultsThe presence of genotype HPV16 in our study was associated with a 12 times greater risk of developing a high-grade lesion, OR = 12.70. The patients with single infections had the highest incidence of CIN2+ (34.1%) with respect to those with multiple infections (10.6%).When we studied in the mHPV infection the prevalence of the combinations between the genotypes, we found that in mHPV16 infections, the combinations HPV16, 18 and HPV16, 31 were the most frequent (55.5%) in CIN3 lesion.
conclusionsOur results suggest that single HPV infections have a greater risk of developing SCC with respect to multiple infections. Multiple HPV infections are relevant only in the first phase of the lesion (CIN1-CIN2), while they are absent in carcinomas, where infections are of a single genotype. In particular, among multiple infections, HPV16 infection with 2 HR genotypes is associated significantly with CIN2 / CIN3 (21/30) and has 4 times greater risk of developing a high-grade lesion. Thus, it is probable that only specific combinations of HPV (HPV16,18 - HPV 16,31) can be associated with a clinically significant impact, while other combinations can simply be correlated because of a common infection or diagnostic method used. Therefore, multiple HPV16 infections with two high-risk genotypes is a major risk of CIN2/CIN3.
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