Observational studyCardiovascular diabetology2020
Relationship between ABO blood groups and cardiovascular disease in type 1 diabetes according to diabetic nephropathy status.
Observational study in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 0 citations in OpenAlex.
- A narrative review of the epidemiological and mechanistic associations between ABO blood groups and diseases: focusing on cardiovascular diseases, cancers, diabetes, malaria, COVID-19 and rheumatic diseases.Annals of medicine · 2026Review
- Are Blood Groups a Predictive Factor in Determining the Severity of Coronary Artery Disease in Patients Undergoing Coronary Heart Surgery?Brazilian journal of cardiovascular surgery · 2026Article
- Relationship Between Blood Groups and Cardiovascular Diseases: Insights From an Algerian Inpatient Study.Cureus · 2024Article
- Non-O blood types are associated with a greater risk of large artery atherosclerosis stroke and dysregulation of cholesterol metabolism: an observational study.Lipids in health and disease · 2024Observational
- Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance.International journal of molecular sciences · 2023Article
- Blood group as a novel predictor of postoperative atrial fibrillation after off-pump coronary artery bypass grafting.Revista da Associacao Medica Brasileira (1992) · 2023Article
- Visualizing novel connections and genetic similarities across diseases using a network-medicine based approach.Scientific reports · 2022Article
- Article
- The potential use of ABO blood group system for risk stratification of COVID-19.Medical hypotheses · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundABO blood groups have previously been associated with cardiovascular disease (CVD) in the general population. This study aimed to investigate the potential relationship between ABO blood groups and CVD in individuals with type 1 diabetes according to diabetic nephropathy (DN) status.
methodsAdults with type 1 diabetes (4531 individuals) from the FinnDiane Study were evaluated. DN was determined by two out of three measurements of urinary albumin excretion rate. Albuminuria was defined as an excretion rate above 20 µg/min. CVD events were identified by linking the data with the Finnish Care Register for Health Care and the Finnish Cause of Death Register. Follow-up ranged from the baseline visit until a CVD event, death or the end of 2017. The impact of ABO blood groups on CVD risk was estimated by multivariable Cox-regression analyses adjusted for traditional risk factors.
resultsAt baseline, the median age was 38.5 (IQR 29.2-47.9) years, 47.5% were female and median duration of diabetes was 20.9 (11.4-30.7) years. There were 893 incident ischemic heart disease (IHD) events, 301 ischemic strokes (IS), and 415 peripheral artery disease (PAD) events during a median follow up of 16.5 (IQR 12.8-18.6) years. The A blood group showed the highest risk of IHD versus the O blood group, when microalbuminuria was present. Comparing the population with microalbuminuria with those with normoalbuminuria, only the A blood group elevated the risk of IHD. This increased risk was neither explained by the FUT2 secretor phenotype nor by the A-genotype distribution. The risk of IS or PAD was no different among the ABO blood groups regardless of diabetic nephropathy stage.
conclusionThe A blood group is a risk factor for IHD in individuals with type 1 diabetes and microalbuminuria.
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