ArticleBMC microbiology2020
Viral metagenomic analysis of fecal samples reveals an enteric virome signature in irritable bowel syndrome.
Article in BMC microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 34 citations in OpenAlex.
- Gut Virome: What's the Role in Irritable Bowel Syndrome?Reviews in medical virology · 2025Review
- Presence of Protozoan Viruses in Vaginal Samples from Pregnant Women and Their Association with Trichomoniasis.Pathogens (Basel, Switzerland) · 2025Article
- Individualized metagenomic network model for colorectal cancer diagnosis: insights into viral regulation of gut microecology.Briefings in bioinformatics · 2025Article
- The cerebrospinal fluid virome in people with HIV: links to neuroinflammation and cognition.Frontiers in microbiology · 2025Article
- Genomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEpFrontiers in microbiology · 2025Article
- Antiviral Activity of Natural Compounds for Food Safety.Food and environmental virology · 2024Review
- Longitudinal analysis of the enteric virome in paediatric subjects from the Free State Province, South Africa, reveals early gut colonisation and temporal dynamics.Virus research · 2024Article
- Article
- The Human Microbiome-A Physiologic Perspective.Comprehensive Physiology · 2024Review
- Review
- Emerging role of the gut microbiome in post-infectious irritable bowel syndrome: A literature review.World journal of gastroenterology · 2023Review
- Article
- Interpersonal variability of the human gut virome confounds disease signal detection in IBD.Communications biology · 2023Article
- The human gut phageome: composition, development, and alterations in disease.Frontiers in microbiology · 2023Review
- The gut virome and the relevance of temperate phages in human health.Frontiers in cellular and infection microbiology · 2023Review
- The Gut Microbiome and Colonic Motility Disorders: A Practical Framework for the Gastroenterologist.Current gastroenterology reports · 2022Review
- Review
- Post-Infectious Irritable Bowel Syndrome after an Epidemic of Gastroenteritis in South of Iran.Middle East journal of digestive diseases · 2022Article
- Whole gut virome analysis of 476 Japanese revealed a link between phage and autoimmune disease.Annals of the rheumatic diseases · 2022Article
- Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundChanges in the enteric microbiota have been suggested to contribute to gastrointestinal diseases, including irritable bowel syndrome. Most of the published work is on bacterial dysbiosis with meager data on the role of the virome in irritable bowel syndrome and other gastrointestinal diseases. In the current study, we therefore aimed to investigate the viral community composition of the gut and test for potential dysbiosis linked to irritable bowel syndrome.
resultsA metagenomics analysis on fecal samples of 50 individuals - 30 of whom met the Rome IV criteria for IBS and 20 healthy controls- was conducted. There was a noticeable alteration in viral taxa observed in association with irritable bowel syndrome when compared to healthy individuals - where some eukaryotic viral taxa noticeably prevail over others. We observed a significant decrease in the diversity and abundance of enteric virome particularly in eukaryotic viruses of Megavirales in patients with irritable bowel syndrome.
conclusionsThese findings shed light on a new hypothesis that the alteration of the viral taxa contributes to the pathogenesis of irritable bowel syndrome and related symptoms, and therefore, pave the way for developing a new diagnostic biomarker or anti-viral drugs for the treatment of irritable bowel syndrome.
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