ArticleBMC cancer2020
Sex-specific impact of patterns of imageable tumor growth on survival of primary glioblastoma patients.
Article in BMC cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 28 citations in OpenAlex.
- Forecasting Chemoradiation Response Midtreatment for High-Grade Gliomas Through Patient-Specific Biology-Based Modeling.International journal of radiation oncology, biology, physics · 2025Article
- Multimodal Explainable Artificial Intelligence for Prognostic Stratification of Patients With Glioblastoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2025Article
- Gender and sex interactions are intrinsic components of cancer phenotypes.Nature reviews. Cancer · 2025Review
- MRI-based digital twins to improve treatment response of breast cancer by optimizing neoadjuvant chemotherapy regimens.NPJ digital medicine · 2025Article
- Mathematical modeling of multicellular tumor spheroids quantifies inter-patient and intra-tumor heterogeneity.NPJ systems biology and applications · 2025Article
- Sex-Specific Differences in Patients withAJNR. American journal of neuroradiology · 2024Article
- Individualized survival prediction and surgery recommendation for patients with glioblastoma.Frontiers in medicine · 2024Article
- Review
- Association of graph-based spatial features with overall survival status of glioblastoma patients.Scientific reports · 2023Article
- Evaluation of RANO Criteria for the Assessment of Tumor Progression for Lower-Grade Gliomas.Cancers · 2023Article
- The Pathological Activation of Microglia Is Modulated by Sexually Dimorphic Pathways.International journal of molecular sciences · 2023Review
- An image-based modeling framework for predicting spatiotemporal brain cancer biology within individual patients.Frontiers in oncology · 2023Article
- PotentFrontiers in oncology · 2023Article
- Advances in computational and translational approaches for malignant glioma.Frontiers in physiology · 2023Review
- Prognostic Factors of Survival in Glioblastoma Multiforme Patients-A Retrospective Study.Diagnostics (Basel, Switzerland) · 2022Article
- Opportunities for improving brain cancer treatment outcomes through imaging-based mathematical modeling of the delivery of radiotherapy and immunotherapy.Advanced drug delivery reviews · 2022Review
- Integrating mechanism-based modeling with biomedical imaging to build practical digital twins for clinical oncology.Biophysics reviews · 2022Review
- Image-based personalization of computational models for predicting response of high-grade glioma to chemoradiation.Scientific reports · 2021Article
- Sex differences in health and disease: A review of biological sex differences relevant to cancer with a spotlight on glioma.Cancer letters · 2021Review
- Sex Differences in Time to Treat and Outcomes for Gliomas.Frontiers in oncology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
26 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundSex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.
methodsCombining multi-modal MR images, biomathematical models, and patient clinical information, this investigation assesses which pretreatment variables have a sex-specific impact on the survival of glioblastoma patients (299 males and 195 females).
resultsAmong males, tumor (T1Gd) radius was a predictor of overall survival (HR = 1.027, p = 0.044). Among females, higher tumor cell net invasion rate was a significant detriment to overall survival (HR = 1.011, p < 0.001). Female extreme survivors had significantly smaller tumors (T1Gd) (p = 0.010 t-test), but tumor size was not correlated with female overall survival (p = 0.955 CPH). Both male and female extreme survivors had significantly lower tumor cell net proliferation rates than other patients (M p = 0.004, F p = 0.001, t-test).
conclusionDespite similar distributions of the MR imaging parameters between males and females, there was a sex-specific difference in how these parameters related to outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.