SynthesisActa orthopaedica2020
Can MRI differentiate between atypical cartilaginous tumors and high-grade chondrosarcoma? A systematic review.
Synthesis in Acta orthopaedica, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Whole-body imaging for distant staging of bone chondrosarcoma: a systematic review.La Radiologia medica · 2025Pooled it
- A Systematic Review of Adjuvant Chemotherapy in Localized Dedifferentiated Chondrosarcoma.Current oncology (Toronto, Ont.) · 2024Pooled it
- The diagnostic value of magnetic resonance imaging-based texture analysis in differentiating enchondroma and chondrosarcoma.Skeletal radiology · 2023Trial
- Wait, scan and then? Exploring the long-term natural course of 119 low-grade central cartilaginous lesions of the long bones with MRI follow-up.European radiology · 2026Article
- Intraosseous tumours of the knee.Skeletal radiology · 2026Review
- Primary Cardiac Chondroma Presenting as a Left Atrial Mass: An Exceptionally Rare Case Report.Anatolian journal of cardiology · 2026Article
- From imaging to omics: deep learning is bridging MRI and liquid biopsy in bone tumor diagnosis.Journal of bone oncology · 2026Review
- Exact radiological-pathological correlation of chondrosarcomas using a patient-specific 3D mold.Skeletal radiology · 2025Article
- Article
- Grading chondroid tumors through MRI radiomics: enchondroma, low-grade chondrosarcoma and higher-grade chondrosarcoma.BMC cancer · 2025Article
- Atypical cartilaginous tumor imaging findings in the distal phalanx of the left thumb: case report and literature review.Frontiers in oncology · 2025Article
- A retrospective external validation study of the Birmingham Atypical Cartilage Tumour Imaging Protocol (BACTIP) for the management of solitary central cartilage tumours of the proximal humerus and around the knee.European radiology · 2024Article
- Preoperative prediction of histopathological grading in patients with chondrosarcoma using MRI-based radiomics with semantic features.BMC medical imaging · 2024Article
- Chondrosarcoma evaluation using hematein-based x-ray staining and high-resolution 3D micro-CT: a feasibility study.European radiology experimental · 2024Article
- Fracture risk after intralesional curettage of atypical cartilaginous tumors.Journal of orthopaedic surgery and research · 2023Article
- Curettage or Resection? A Review on the Surgical Treatment of Low-Grade Chondrosarcomas.Cureus · 2023Article
- Chondrosarcoma: A Clinical Review.Journal of clinical medicine · 2023Review
- Classification of Chondrosarcoma: From Characteristic to Challenging Imaging Findings.Cancers · 2023Review
- Differentiating Enchondromas and Atypical Cartilaginous Tumors in Long Bones with Computed Tomography and Magnetic Resonance Imaging.Diagnostics (Basel, Switzerland) · 2022Article
- The influence of site on the incidence and diagnosis of solitary central cartilage tumours of the femur. A 21Journal of clinical orthopaedics and trauma · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and purpose - Adequate staging of chondroid tumors at diagnosis is important as it determines both treatment and outcome. This systematic review provides an overview of MRI criteria used to differentiate between atypical cartilaginous tumors (ACT) and high-grade chondrosarcoma (HGCS).Patients and methods - For this systematic review PubMed and Embase were searched, from inception of the databases to July 12, 2018. All original articles describing MRI characteristics of pathologically proven primary central chondrosarcoma and ACT were included. A quality appraisal of the included papers was performed. Data on MRI characteristics and histological grade were extracted by 2 reviewers. Meta-analysis was performed if possible. The study is registered with PROSPERO, CRD42018067959.Results - Our search identified 2,132 unique records, of which 14 studies were included. 239 ACT and 140 HGCS were identified. The quality assessment showed great variability in consensus criteria used for both pathologic and radiologic diagnosis. Due to substantial heterogeneity we refrained from pooling the results in a meta-analysis and reported non-statistical syntheses. Loss of entrapped fatty marrow, cortical breakthrough, and extraosseous soft tissue expansion appeared to be present more often in HGCS compared with ACT.Interpretation - This systematic review provides an overview of MRI characteristics used to differentiate between ACT and HGCS. Future studies are needed to develop and assess more reliable imaging methods and/or features to differentiate ACT from HGCS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.